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Displaying results 1041 - 1050 of 10000 in total
  1. Target

    Cocaine esterase

    go.drugbank.com/bio_entities/BE0001413
    TargetEnzymeRhodococcus sp. (strain MB1 Bresler)

    Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. … Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere

    Polypeptides: Cocaine esterase
  2. Target

    Esterase EstB

    go.drugbank.com/bio_entities/BE0003305
    TargetPseudomonas marginata

    Acts on short-chain (C4-C6) fatty acid esters and triglycerides, including tertiary alcohol esters. Activity on p-nitrophenyl esters is generally higher than on o-nitrophenyl esters. Lacks beta-lactamase activity; it hydrolyzes the ester...

    Polypeptides: Esterase EstB
  3. Drug

    Aztreonam

    go.drugbank.com/drugs/DB00355
    ApprovedInvestigational

    A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. … It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid, 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl) -2- {[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino} -2- oxoethylidene]amino}oxy)-2-methylpropanoic acid
  4. Indication

    Perioperative Bleeding caused by Hemophilia A

    go.drugbank.com/conditions/DBCOND0089513
    Drugs: Anti-inhibitor coagulant complex
    Synonyms: Perioperative Bleeding caused by Hemophilia A
  5. Indication

    Symptomatic Botulism caused by Clostridium botulinum serotype A

    go.drugbank.com/conditions/DBCOND0093883
    Drugs: Equine Botulinum Neurotoxin A Immune FAB2
    Synonyms: Symptomatic Botulism caused by Clostridium botulinum serotype A
  6. Drug

    2-Hydroxyestradiol

    go.drugbank.com/drugs/DB07706
    Experimental

    2-Hydroxyestradiol is classified as an endogenous steroid, catechol estrogen, and metabolite of estradiol. It is also a positional isomer of estriol. [A31630]

    Categories: EstranesSynonyms: (17β)-estra-1,3,5(10)-triene-2,3,17-triol, 2-OH-Estradiol
  7. Drug

    Cephalexin

    go.drugbank.com/drugs/DB00567
    ApprovedInvestigationalVet approved

    [A179071,A179074] This antibiotic contains a beta lactam and a dihydrothiazide. … [A179071] Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.[A179083,L6547] Cephalexin was approved by the FDA on 4 January 1971.

    Synonyms: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acidInternational brands: L-Keflex
  8. Pathway

    Estrone Metabolism

    smpdb.ca/view/SMP0030880
    Metabolic

    Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex hormone. Estrone is synthesized from cholesterol and secreted from gonads. … Estrone sulfate and estrone glucuronide are the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens.

    Drugs: Ademetionine · NADH · Estrone · Estradiol · Magnesium cation · Mesoheme +3 more
  9. Drug

    Guaifenesin

    go.drugbank.com/drugs/DB00874
    ApprovedInvestigationalVet approved

    After the negotiation between FDA and major manufacturers, a voluntary transition of labels for not using guaifenesin in children under the age of 4 years was endorsed by FDA in 2008 [F4525]. … Since that time the agent has been a combination component of various prescription and non-prescription over-the-counter cough and cold products and is currently a widely available over-the-counter generic

    Mixtures: Entex LA, Entex LAInternational brands: Duratuss G
  10. Drug

    Darbepoetin alfa

    go.drugbank.com/drugs/DB00012
    ApprovedInvestigational

    Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.

    Products: ARANESP® 100µG SOLUCION INYECTABLE EN JERINGA PRELLENADA, ARANESP® 50 MCG SOLUCIÓN INYECTABLE EN JERINGA PRELLENADA