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Displaying results 1051 - 1060 of 10000 in total
  1. Drug

    Azithromycin

    go.drugbank.com/drugs/DB00207
    ApprovedInvestigational

    In March 2020, a small study was funded by the French government to investigate the treatment of COVID-19 with a combination of azithromycin and the anti-malaria drug [hydroxychloroquine]. … Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration [A174172]. It was initially approved by the FDA in 1991 [A174175].

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: Zithromax Cap 250mg, ZITHROMAX TR-SAFT K B 25KG
  2. Drug

    Trimethoprim

    go.drugbank.com/drugs/DB00440
    ApprovedInvestigationalVet approved

    [L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of … Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it

    Synonyms: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamineMixtures: EUSAPRIM K SUS F KDR, TRIMETROPINA SULFA F MK
  3. Drug

    Edoxudine

    go.drugbank.com/drugs/DB13421
    ApprovedWithdrawn

    It was later recognized to be effective in vivo in a preclinical model of keratitis caused by herpes virus. … [A32643] It was developed by McNeil Pharmaceutical and approved by Health Canada on December 31, 1992. This medication was later discontinued from the market in 1998.[L1113]

    Synonyms: 2'-Deoxy-5-ethyluridine, 5-Ethyl-2'-deoxyuridineCategories: Heterocyclic Compounds, 1-Ring
  4. Indication

    Migraine With Aura

    go.drugbank.com/conditions/DBCOND0031385
    Drugs: Eletriptan · Frovatriptan · Meloxicam · Rimegepant · Rizatriptan · Ubrogepant
    Synonyms: Möbius' syndrome I
  5. Drug

    Moxifloxacin

    go.drugbank.com/drugs/DB00218
    ApprovedInvestigational

    Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. … Moxifloxacin is a synthetic fluoroquinolone antibiotic agent.

    Synonyms: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4as,7as)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acidMixtures: TQ OFTAMOX D UD®, TQ OFTAMOX® D UD
  6. Drug

    Mirtazapine

    go.drugbank.com/drugs/DB00370
    ApprovedInvestigational

    [A177946] This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder. … [A178144,L6160] In addition to its beneficial effects in depression, mirtazapine has been reported to be efficacious in the off-label management of various other conditions.

    Synonyms: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine, 6-AzamianserinCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 Substrates
  7. Target

    Tumor necrosis factor receptor superfamily member 1A

    go.drugbank.com/bio_entities/BE0001139
    TargetHumans

    Receptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation wh...

    Synonyms: TNFR-I, Tumor necrosis factor receptor type I
  8. Target

    Carnitine O-palmitoyltransferase 1, liver isoform

    go.drugbank.com/bio_entities/BE0000406
    TargetHumans

    Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (PubMed:38016475). … Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase

    Synonyms: CPT I, Carnitine O-palmitoyltransferase I, liver isoform
  9. Target

    Annexin A1

    go.drugbank.com/bio_entities/BE0000422
    TargetHumans

    Has no effect on unstimulated T cells (PubMed:17008549). … Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678).

    Synonyms: Annexin I, Lipocortin I
  10. Drug

    Water

    go.drugbank.com/drugs/DB09145
    ApprovedInvestigational

    Water is a liquid at standard ambient temperature and pressure, but it often co-exists on Earth with its solid state, ice; and gaseous state, steam (water vapor). … As a chemical compound, a water molecule contains one oxygen and two hydrogen atoms that are connected by covalent bonds.

    Mixtures: K-Mart SmartSense First Aid Contains 101 Pieces, K-Mart SmartSense First Aid Contains 303 PiecesProducts: N/A, Dorama-Neo