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Displaying results 1051 - 1060 of 1711 in total
  1. Drug

    Amorolfine

    go.drugbank.com/drugs/DB09056
    ApprovedWithdrawn

    It is approved for sale over the counter in Australia and the UK (recently re-classified to over the counter status), and is approved for the treatment of toenail fungus by prescription in other countries

  2. Drug

    Pentoxyverine

    go.drugbank.com/drugs/DB11186
    ApprovedWithdrawn

    It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists [A32160].

  3. Drug

    Naloxegol

    go.drugbank.com/drugs/DB09049
    ApprovedInvestigational

    The advantage of naloxegol over the opioid antagonist naloxone is that its PEGylated structure allows for high selectivity for peripheral opioid receptors and lack of entry into the central nervous system

    Categories: Peripheral Opioid Receptor Antagonists
  4. Drug

    Trimetazidine

    go.drugbank.com/drugs/DB09069
    ApprovedInvestigational

    Trimetazidine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies. Trimetazidine has been studied as a treatment for angin...

  5. Target

    High affinity immunoglobulin epsilon receptor subunit alpha

    go.drugbank.com/bio_entities/BE0000015
    TargetHumans

    High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells.

    Polypeptides: High affinity immunoglobulin epsilon receptor subunit alphaSynonyms: IgE Fc receptor subunit alpha
  6. Target

    High affinity immunoglobulin gamma Fc receptor I

    go.drugbank.com/bio_entities/BE0000710
    TargetCarrierHumans

    High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

    Polypeptides: High affinity immunoglobulin gamma Fc receptor ISynonyms: IgG Fc receptor I
  7. Target

    Gamma-aminobutyric acid receptor subunit alpha-6

    go.drugbank.com/bio_entities/BE0000764
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:8632757). GABA-gated chloride channels, also named GABA(A) receptors (G...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-6Synonyms: GABA(A) receptor subunit alpha-6
  8. Target

    Tyrosine-protein phosphatase non-receptor type 4

    go.drugbank.com/bio_entities/BE0000980
    TargetHumans

    Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively re...

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 4
  9. Target

    Tumor necrosis factor receptor superfamily member 1A

    go.drugbank.com/bio_entities/BE0001139
    TargetHumans

    Receptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor.

    Polypeptides: Tumor necrosis factor receptor superfamily member 1ASynonyms: Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I
  10. Target

    Triggering receptor expressed on myeloid cells 1

    go.drugbank.com/bio_entities/BE0001288
    TargetHumans

    By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute … Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102).

    Polypeptides: Triggering receptor expressed on myeloid cells 1Synonyms: Triggering receptor expressed on monocytes 1