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Displaying results 1051 - 1060 of 10000 in total
  1. Drug

    Metformin

    go.drugbank.com/drugs/DB00331
    ApprovedInvestigational

    Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes. … It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels.

    Mixtures: PIOGLITAZONE E METFORMINA EG, PIOGLITAZONE E METFORMINA EGCategories: MATE 1 Substrates, MATE 2 Substrates
  2. Drug

    Baricitinib

    go.drugbank.com/drugs/DB11817
    ApprovedInvestigational

    [A248400] The EC later approved baricitinib for the treatment of atopic dermatitis, making it the first JAK inhibitor used for this indication in Europe. … [A248405] While baricitinib was granted emergency use as a treatment for COVID-19 in combination with [remdesivir] under the Emergency Use Authorization (EUA) in November 2020,[L22619] the FDA fully approved

    Categories: MATE 2 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: UNAMİTY 4 MG FİLM KAPLI TABLET, 7 ADET, UNAMİTY 2 MG FİLM KAPLI TABLET, 7 ADET
  3. Drug

    Demecarium

    go.drugbank.com/drugs/DB00944
    Approved

    The outflow of the aqueous humor is facilitated, which leads to a reduction in intraocular pressure. … Demecarium is an indirect-acting parasympathomimetic agent that is used to treat glaucoma. It is a cholinesterase inhibitor or an anticholinesterase.

  4. Drug

    Protokylol

    go.drugbank.com/drugs/DB06814
    ApprovedVet approved

    Protokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States.

    Categories: Agents to Treat Airway Disease, Adrenergic beta-2 Receptor AgonistsProducts: OPTİCAİNE %0.5 GÖZ DAMLASI, ÇÖZELTİ 5 ML
  5. Pathway

    Cystathionine beta-Synthase Deficiency

    smpdb.ca/view/SMP0000177
    Disease

    Cystathionine Beta-Synthase Deficiency (CBS Deficiency; Homocystinuria) is an autosomal recessive disease caused by a mutation in the CBS gene which codes for cystathionine beta-synthase. A deficiency in this enzyme results in accumulati...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  6. Pathway

    Methionine Adenosyltransferase Deficiency

    smpdb.ca/view/SMP0000221
    Disease

    Methionine adenosyltransferase (MAT; Hypermethioninemia; MAT I/III deficiency) deficiency is caused by mutations in the MAT1A gene which causes isolated hypermethioninemia. MAT catalyzes the formation of adenosylmethionine from methionin...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  7. Pathway

    Hypermethioninemia

    smpdb.ca/view/SMP0000341
    Disease

    This gene is responsible for Adenosylhomocysteinase, an enzyme which takes S-adenosyl homocysteine as input, and produces homocysteine as its output.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  8. Pathway

    Methionine Metabolism

    smpdb.ca/view/SMP0000033
    Metabolic

    in a methylated product plus S-adenosylhomocysteine, and the conversion of S-adenosylhomocysteine to produce the compounds homocysteine and adenosine. … These pathways have three common reactions with both pathways including the transformation of methionine to S-adenosylmethionine (SAM), the use of SAM in many different transmethylation reactions resulting

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  9. Pathway

    Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)

    smpdb.ca/view/SMP0000340
    Disease

    Methylenetetrahydrofolate reductase deficiency (MTHFRD; Homocystinuria due to defect of n(5,10)-methylene THF deficiency) is caused by a defect in the MTHFR gene which codes for methylenetetrahydrofolate reductase. Methylenetetrahydrofol...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase
  10. Pathway

    Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type

    smpdb.ca/view/SMP0125684
    Disease

    Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, also known as methionine synthase deficiency or methylcobalamin deficiency, cblG type, is a rare inborn error of metabolism (IEM) and a...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase