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Displaying results 1061 - 1070 of 2828 in total
  1. Drug

    4-O-Demethylpenclomedine

    go.drugbank.com/drugs/DB06331
    Experimental

  2. Drug

    Rizatriptan

    go.drugbank.com/drugs/DB00953
    ApprovedInvestigational

    Rizatriptan is a second-generation triptan and a selective 5-HT1B and 5-HT1D receptor agonist. Used in the treatment of migraines, rizatriptan was first approved in the US in 1998. Rizatriptan is available in oral tablets, orally disinte...

  3. Drug

    Pinacidil

    go.drugbank.com/drugs/DB06762
    Approved

    Pinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood press...

    Categories: Membrane Transport Modulators
  4. Target

    ATP-binding cassette sub-family C member 3

    go.drugbank.com/bio_entities/BE0001061
    TransporterHumans

    Can also transport glutathione conjugates such as leukotriene C4 (LTC4) (PubMed:11581266). Transports various xenobiotics. … May selectively transport steroid sulfate conjugates.

    Synonyms: Multi-specific organic anion transporter D, Canalicular multispecific organic anion transporter 2Function: ABC-type bile acid transporter activity
  5. Target

    Retinal-specific phospholipid-transporting ATPase ABCA4

    go.drugbank.com/bio_entities/BE0013860
    TransporterHumans

    Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine (N-Ret-PE) from … This transport activity ensures that all-trans-retinal generated from photoexcitation and 11-cis-retinal not needed for the regeneration of rhodopsin and cone opsins are effectively cleared from the photoreceptors

    Synonyms: RIM ABC transporter, Retinal-specific ATP-binding cassette transporter
  6. Target

    Mitochondrial ATP synthase F1 domain

    go.drugbank.com/bio_entities/BE0010209
    TargetEnzymeHumans

    by electron transport complexes of the respiratory chain (Probable). … by electron transport complexes of the respiratory chain (PubMed:37244256).

    Polypeptides: ATP synthase F(1) complex subunit alpha, mitochondrial, ATP synthase F(1) complex subunit beta, mitochondrial
  7. Drug

    NN344

    go.drugbank.com/drugs/DB05115
    Experimental

    NN344 is a neutral, soluble long-acting human insulin analogue with 24 hour coverage by once daily injection. NN344 has a very flat and predictable action profile. The product is intended for basal insulin treatment of diabetes mellitus.

  8. Target

    Na(+)/dicarboxylate cotransporter 3

    go.drugbank.com/bio_entities/BE0000611
    TransporterHumans

    Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10794676). … Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10794676, PubMed:10992006).

    Synonyms: Na(+)-coupled carboxylate transporter 3, Sodium-dependent high-affinity dicarboxylate transporter 2Function: alpha-ketoglutarate transmembrane transporter activity
  9. Drug

    Telavancin

    go.drugbank.com/drugs/DB06402
    ApprovedInvestigational

    Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria.

  10. Drug

    rhMBL

    go.drugbank.com/drugs/DB05237
    Investigational

    rhMBL is a protein therapeutic being developed by Enzon for the prevention and treatment of severe infections in individuals with low levels of Mannose-Binding Lectin (MBL). Over 10 percent of the general population is estimated to be MB...