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Displaying results 1061 - 1070 of 1186 in total
  1. Drug

    Vasopressin

    go.drugbank.com/drugs/DB00067
    ApprovedInvestigational

    Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour. Vasopressin is v...

  2. Indication

    XLH

    go.drugbank.com/conditions/DBCOND0125908
    Drugs: Burosumab
    Synonyms: Calcitriol receptor defect
  3. Target

    P2X purinoceptor 3

    go.drugbank.com/bio_entities/BE0009818
    TargetHumans

    Extracellular ATP-activated non-selective cation channel (PubMed:10440098, PubMed:27626375, PubMed:29674445, PubMed:31232692). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nocicepti...

    Synonyms: ATP receptor, Purinergic receptor
  4. Target

    P2X purinoceptor 2

    go.drugbank.com/bio_entities/BE0009820
    TargetHumans

    ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic r...

    Synonyms: ATP receptor, Purinergic receptor
  5. Target

    P2 Purinoceptors

    go.drugbank.com/bio_entities/BE0009827
    Target

    Putative receptor for purines coupled to G proteins … Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system

    Polypeptides: Lysophosphatidic acid receptor 4, Lysophosphatidic acid receptor 6Synonyms: LPA receptor 4, LPA receptor 6
  6. Target

    P2X purinoceptor 4

    go.drugbank.com/bio_entities/BE0005793
    TargetHumans

    Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166).

    Synonyms: ATP receptor, Purinergic receptor
  7. Target

    P2Y purinoceptor 1

    go.drugbank.com/bio_entities/BE0009816
    TargetHumans

    Receptor for extracellular adenine nucleotides such as ADP (PubMed:25822790, PubMed:9038354, PubMed:9442040).

    Synonyms: ADP receptor, Purinergic receptorFunction: A1 adenosine receptor binding
  8. Drug

    Efonidipine

    go.drugbank.com/drugs/DB09235
    Investigational

    Efonidipine is a calcium channel blocker of the dihydropyridine class, commercialized by Shionogi & Co. (Japan). Initially, it was marketed in 1995 under the trade name, Landel. The drug has been shown to block T-type in addition to ...

  9. Target

    Cubilin

    go.drugbank.com/bio_entities/BE0000936
    TargetTransporterHumans

    Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:10371504, PubMed:11606717, PubMed:11717447, PubMed:14576052, PubMed:9572993).

    Synonyms: 460 kDa receptor, Intestinal intrinsic factor receptor
  10. Target

    P2Y purinoceptor 2

    go.drugbank.com/bio_entities/BE0002401
    TargetHumans

    Receptor for ATP and UTP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP

    Synonyms: ATP receptor, P2U receptor 1Function: A1 adenosine receptor binding