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Isosorbide Mononitrate Action Pathway
smpdb.ca/view/SMP0125275Drug actionIt is then metabolized in the cytosol into nitric oxide by P450 enzymes, xanthine oxidoreductase (XO), glutathione-S-transferase (GST), or cytosolic aldehyde dehydrogenase isoforms.
Drugs: Nitric Oxide · Isosorbide mononitrate · Potassium cation · Calcium · Magnesium cation · Pyrophosphoric acidEnzymes: Glutathione S-transferase Mu 1Ruxolitinib Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126971Drug actionRuxolitinib is a medication used to manage and treat myelofibrosis, polycythemia vera, and steroid-refractory acute graft-versus-host disease. It is in the Janus Kinase inhibitor class of medications. Ruxolitinib is a selective and poten...
Drugs: RuxolitinibEnzymes: S-phase kinase-associated protein 2Nerofe
go.drugbank.com/drugs/DB14786InvestigationalNerofe is under investigation in clinical trial NCT03059615 (A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS).
Synonyms: WWTFFLPSTLWERK, (ALL D)-, TRP-TRP-THR-PHE-PHE-LEU-PRO-SER-THR-LEU-TRP-GLU-ARG-LYS, (ALL D)-Cepeginterferon alfa-2B
go.drugbank.com/drugs/DB12814InvestigationalCepeginterferon alfa-2B is under investigation in clinical trial NCT01889433 (An Open-label Comparative Efficacy and Safety Study of Algeron (Cepeginterferon Alfa-2b) in Treatment-naive Patients With Chronic … Hepatitis C).
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsSynonyms: Cepeginterferon Alfa 2 B, Pegylated human interferon A-2BGlimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigationalIt is sometimes classified as a third-generation SU because it has larger substitutions than other second-generation SUs. … Compared to [glipizide], another second SU drug, glimepiride has a longer duration of action.
Mixtures: AMARYL® M SR, AMARYL® M SRCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesEvalstotug
go.drugbank.com/drugs/DB19410InvestigationalEvalstotug is under investigation in clinical trial NCT05271604 (A Phase 2 Open Label Study of BA3021 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck).
Synonyms: Immunoglobulin G1-kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)], monoclonal antibody, Immunoglobulin G1 [de-448-lysine], anti-(human cytotoxic T-lymphocyte-associated protein 4) (human monoclonal BA3071 γ1-chain), disulfide with human monoclonal BA3071 κ-chain, dimerIntracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb.ca/view/SMP0000320SignalingThe adenosine receptor A2a activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortVoretigene neparvovec
go.drugbank.com/drugs/DB13932ApprovedInvestigationalIt is not pathogenic and it causes a very mild immune response. … Voretigene Neparvovec-rzyl (VN-rzyl) is an adeno-associated virus vector-based gene therapy.[L1094] An adeno-associated virus is a small virus that infects humans and other primates.
Aspartyl-alanyl-diketopiperazine
go.drugbank.com/drugs/DB14940InvestigationalAspartyl-alanyl-diketopiperazine is under investigation in clinical trial NCT03349645 (An Open Label Extension Study to Assess the Safety of Long-Term Treatment With Ampion for Severe OA of the Knee).
Remtolumab
go.drugbank.com/drugs/DB15128InvestigationalRemtolumab is under investigation in clinical trial NCT02433340 (Phase 2, Multicenter, Open-Label Extension (OLE) Study With ABT-122 in Rheumatoid Arthritis Subjects Who Have Completed the Preceding M12