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Displaying results 1081 - 1090 of 2674 in total
  1. Drug

    Erdafitinib

    go.drugbank.com/drugs/DB12147
    ApprovedInvestigational

    In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for … [L5956, L5959] At the same time, the FDA also approved the therascreen FGFR RGQ RT-PCR Kit (Qiagen) for utilization as a companion diagnostic with erdafitinib for selecting patients for the indicated therapy

    Categories: Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors
  2. Drug

    Lemborexant

    go.drugbank.com/drugs/DB11951
    ApprovedInvestigational

    [L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits, but rather an inability to … Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.

    Categories: Orexin Receptor Antagonists
  3. Drug

    Diclofenac

    go.drugbank.com/drugs/DB00586
    ApprovedInvestigationalVet approved

    Diclofenac was first approved by the FDA in July 1988 under the trade name Voltaren, marketed by Novartis (previously Ciba-Geigy).[L7360]

    Mixtures: DICLOVITH-B-FRT, VITAX-FLAProducts: CLODIFEN % 5 JEL ,1 TÜP, CLODIFEN % 1 JEL ,1 TÜP
  4. Drug

    Larotrectinib

    go.drugbank.com/drugs/DB14723
    ApprovedInvestigational

    It was notable for being the second tissue-agnostic chemotherapy ever approved by the FDA.[L4847]. On April 10, 2025, the FDA granted full drug approval.[L52805] … [L49821] Larotrectinib was granted accelerated approval by the FDA in November 2018 for the treatment of Trk-positive solid tumors.

    Categories: Tropomyosin Receptor Kinases Inhibitors
  5. Target

    High affinity immunoglobulin epsilon receptor subunit alpha

    go.drugbank.com/bio_entities/BE0000015
    TargetHumans

    High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells.

    Polypeptides: High affinity immunoglobulin epsilon receptor subunit alphaSynonyms: IgE Fc receptor subunit alpha
  6. Target

    High affinity immunoglobulin gamma Fc receptor I

    go.drugbank.com/bio_entities/BE0000710
    TargetCarrierHumans

    High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

    Polypeptides: High affinity immunoglobulin gamma Fc receptor ISynonyms: IgG Fc receptor I
  7. Target

    Gamma-aminobutyric acid receptor subunit alpha-6

    go.drugbank.com/bio_entities/BE0000764
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:8632757). GABA-gated chloride channels, also named GABA(A) receptors (G...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-6Synonyms: GABA(A) receptor subunit alpha-6
  8. Target

    Tyrosine-protein phosphatase non-receptor type 4

    go.drugbank.com/bio_entities/BE0000980
    TargetHumans

    Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively re...

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 4
  9. Target

    Tumor necrosis factor receptor superfamily member 1A

    go.drugbank.com/bio_entities/BE0001139
    TargetHumans

    Receptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor.

    Polypeptides: Tumor necrosis factor receptor superfamily member 1ASynonyms: Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I
  10. Target

    Triggering receptor expressed on myeloid cells 1

    go.drugbank.com/bio_entities/BE0001288
    TargetHumans

    By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute … Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102).

    Polypeptides: Triggering receptor expressed on myeloid cells 1Synonyms: Triggering receptor expressed on monocytes 1