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GTP-binding protein Rheb
go.drugbank.com/bio_entities/BE0004594TargetHumansIn response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059) … In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change
Synonyms: Ras homolog enriched in brainClarithromycin
go.drugbank.com/drugs/DB01211ApprovedInvestigationalClarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration. … Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit.
Mixtures: HELIPAK 500 + 30 + 1000mg TEDAVİ PAKETİ, 7 TABLETCategories: P-glycoprotein inhibitors, P-glycoprotein substratesMeloxicam
go.drugbank.com/drugs/DB00814ApprovedInvestigationalVet approved[A190189] With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is available in oral, transdermal, and intravenous formulations. … It is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract effects, however, this is a topic of controversy.[A190198,A190201]
Mixtures: NURO-B, NURO-BCategories: COX-2 Inhibitors, Cytochrome P-450 SubstratesIoversol
go.drugbank.com/drugs/DB09134ApprovedInvestigationalIoversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. … [L41780] Iodine has a high atomic density, which gives it the ability to attenuate X-rays.
Categories: Compounds used in a research, industrial, or household setting, X-Ray Contrast ActivitySynonyms: N,N'-Bis (2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl) -glycolamido] -2,4,6-triiodoisophthalamideHuntington's Disease (HD)
go.drugbank.com/conditions/DBCOND0053941Synonyms: [X]Dementia in Huntington's disease (disorder)N-myc proto-oncogene protein
go.drugbank.com/bio_entities/BE0010382TargetHumansPositively regulates the transcription of MYCNOS in neuroblastoma cells
Synonyms: Class E basic helix-loop-helix protein 37Solute carrier organic anion transporter family member 4A1
go.drugbank.com/bio_entities/BE0003656TransporterHumansMay be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. … -triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in
Synonyms: OATP-E, Organic anion-transporting polypeptide ESilver cation
go.drugbank.com/drugs/DB14521InvestigationalMixtures: Silver Ion Antibacterial Gel, Ancos Silver Ion Hand SanitizerSynonyms: Silver, ion (Ag1+)Clopidogrel
go.drugbank.com/drugs/DB00758ApprovedInvestigationalin recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and … Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.
Mixtures: CLOPIDOGREL E ACIDO ACETILSALICILICO VIATRIS, CLOPIDOGREL E ACIDO ACETILSALICILICO VIATRISCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates