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Lumateperone Dopamine Action Action Pathway
smpdb.ca/view/SMP0126694Drug actionLumateperone, also known as ITI-007, is approved for the treatment of schizophrenia in adults. It is also approved for the treatment of depressive episodes associated with bipolar disorder (i.e. bipolar depression) in adults, as monother...
Asenapine Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126737Drug actionAsenapine is a serotonin, dopamine, noradrenaline, and histamine antagonist in which asenapine possess more potent activity with serotonin receptors than dopamine. Asenapine is an atypical antipsychotic multireceptor neuroleptic drug whi...
Pipotiazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126810Drug actionPipotiazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic...
Metoclopramide - Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126993Drug actionMetoclopramide is a dopamine receptor antagonist and has been approved by the FDA to treat nausea and vomiting in patients with gastroesophageal reflux disease or diabetic gastroparesis by increasing gastric motility.. Metoclopramide wor...
Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps)
smpdb.ca/view/SMP0000488DiseaseBH4-deficient hyperphenylalaninemia has several causes. One such cause is a PTS deficiency resultant from a genetic mutation. (In particular, a mutation in the gene encoding 6-pyruvoyl-tetrahydropterin synthase.) The mutation is autosoma...
Segawa Syndrome
smpdb.ca/view/SMP0000490DiseaseSegawa syndrome is a condition in which the affected individual has a clumsy or unusual gait, and experiences involuntary muscle contractions and uncontrolled movements (dystonia). Some cases are mild, while others can be severe. The beg...
Brexpiprazole Dopamine Agonist Action Pathway
smpdb.ca/view/SMP0126698Drug actionAlthough the exact mechanism of action of brexpiprazole in psychiatric disorders has not been fully elucidated, the efficacy of brexpiprazole may be attributed to combined partial agonist activity at 5-HT1A and dopamine D2 receptors, and...
Amine Oxidase Serotonin
smpdb.ca/view/SMP0130456PhysiologicalThe monoamine oxidase is an enzyme that catalyzes the oxidative deamination of many amines like serotonin, norepinephrine, epinephrine, and dopamine. There are 2 isoforms of this protein: A and B. The first one is found in cells located ...
Amoxapine SSRI Action Pathway
smpdb.ca/view/SMP0126502Drug actionAmoxapine is a second-generation tricyclic dibenzoxazepine antidepressant, chemically distinct from the dibenzodiazepines, dibenzocycloheptenes, and dibenzoxepines. It has a mild sedative component to its action. The mechanism of its cli...
Pterine Biosynthesis
smpdb.ca/view/SMP0000005MetabolicFolates are very important cofactors that provide support for many biosynthetic reactions. The reactions depicted in this pathway include reactions that are paired with transports, within the cell, travelling intracellularly, which allow...