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Displaying results 101 - 110 of 1073 in total
  1. Pathway

    Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone

    smpdb.ca/view/SMP0000333
    Signaling

    In the ovary, the FSH receptor is necessary for follicular development and is expressed on the granulosa cells. … In the male the FSH receptor has been identified on the Sertoli cells that are critical for spermatogenesis.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Follicle-stimulating hormone receptor
  2. Pathway

    Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin

    smpdb.ca/view/SMP0000338
    Signaling

    LHCGRs are found in the ovary, testis, and many extragonadal tissues.In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. … The LHCGRs receptor activates G(s) proteins which lead to the activation of Adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (Protein Kinase A) which phosphorylates down

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Lutropin-choriogonadotropic hormone receptor
  3. Drug

    Mirvetuximab

    go.drugbank.com/drugs/DB16235
    Investigational

    Synonyms: Immunoglobulin g1, anti-(human folate receptor .alpha.) (human-mus musculus monoclonal m9346a heavy chain), disulfide with human-mus musculus monoclonal m9346a light chain, dimer
  4. Drug

    Dextromethorphan

    go.drugbank.com/drugs/DB00514
    ApprovedInvestigational

    Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethor...

    Mixtures: K.B. FEDAMOLCategories: NMDA Receptor Antagonists, Sigma-1 Receptor Agonists
  5. Drug

    KITE-222

    go.drugbank.com/drugs/DB17195
    Investigational

    Synonyms: An autologous chimeric antigen receptor (CAR) T-cell therapy engineered to express an antibody-derived single-chain variable fragment that recognizes C-type lectin-like molecule-1 (CLL-1)
  6. Pathway

    Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway

    smpdb.ca/view/SMP0126347
    Drug action

    Ziconotide, also known as SNX-111, is an N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and sy...

    Drugs: Glutamic acid · Calcium · Sar9, Met (O2)11-Substance P · Ziconotide
    Enzymes: Substance-P receptor, Glutamate [NMDA] receptor subunit 3B
  7. Drug

    Telitacicept

    go.drugbank.com/drugs/DB18312
    Investigational

    Synonyms: 13-118-tumor necrosis factor receptor superfamily protein tnfrsf13b (human extracellular domain fragment) fusion protein with immunoglobulin g1, (human rc18 fc fragment), dimer, (L120>A,L121>E,G123>A,A216>S,P217>S)-TACI (TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY PROTEIN TNFRSF13B) HUMAN EXTRACELLULAR DOMAIN FRAGMENT (13-118)-PEPTIDE
  8. Drug

    Pabinafusp alfa

    go.drugbank.com/drugs/DB15633
    Investigational

    Pabinafusp alfa is under investigation in clinical trial NCT03568175 (A Study of JR-141 in Patients With Mucopolysaccharidosis II).

    Synonyms: Immunoglobulin G1-kappa, anti-(human transferrin receptor 1, tfr1) humanized monoclonal antibody, fused with human iduronate-2-sulfatase, glycoform alfa:, IMMUNOGLOBULIN G1, ANTI-(HUMAN TRANSFERRIN RECEPTOR) (HUMAN-MUS MUSCULUS MONOCLONAL JR-141 .GAMMA.1-CHAIN) FUSION PROTEIN WITH PEPTIDE (SYNTHETIC 2-AMINO ACID LINKER) FUSION PROTEIN WITH HUMAN IDURONATE
  9. Drug

    Lonigutamab

    go.drugbank.com/drugs/DB18940
    Investigational

    Lonigutamab is under investigation in clinical trial NCT05683496 (Efficacy and Safety of Lonigutamab in Subjects With Thyroid Eye Disease (TED)).

    Synonyms: Immunoglobulin g1-kappa, anti-(homo sapiens igf1r (insulin like growth factor 1 receptor, igf1-r, igf-1r, cd221)), humanized monoclonal antibody, Immunoglobulin g1 (de-c-terminal-lysine), anti-(human insulin-like growth factor i receptor) (human-mus musculus monoclonal hz208f2-4 .gamma.1-chain), disulfide with human-mus musculus monoclonal hz208f2
  10. Drug

    Briquilimab

    go.drugbank.com/drugs/DB18136
    Investigational

    Briquilimab is a humanized aglycosylated IgG1 kappa monoclonal antibody targeting CD117 (cKit).

    Synonyms: IMMUNOGLOBULIN G1 (297-GLUTAMINE), ANTI-(HUMAN C-KIT RECEPTOR) (HUMAN-MUS MUSCULUS MONOCLONAL JSP191 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL JSP191 .KAPPA.-CHAIN, DIMER