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Activin receptor type-1-like
go.drugbank.com/bio_entities/BE0000459TargetHumansType I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. … On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.
Synonyms: TSR-I, TGF-B superfamily receptor type ISotorasib
go.drugbank.com/drugs/DB15569ApprovedInvestigational[A187550] Mutant KRAS discovered in 1982 but was not considered a druggable target until the mid-2010s.[A235168] It is the first experimental KRAS inhibitor. … Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-(1M)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2- methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one, Kras G12C inhibitor 9Mavacamten
go.drugbank.com/drugs/DB14921ApprovedInvestigationalIt received initial US FDA approval in 2022, and it is one of the first myosin inhibitors to be used in humans. … [A248440] Mavacamten was also approved by Health Canada in October 2022 and by EMA in July 2023 for the same indication.[L44106,L47471]
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesSynonyms: 6-(((1S)-1-Phenylethyl)amino)-3-(propan-2-yl)-1,2,3,4 tetrahydropyrimidine-2,4-dioneFurosemide
go.drugbank.com/drugs/DB00695ApprovedInvestigationalVet approvedFurosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. … [L7961] It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body.
Mixtures: SPIRO D TABLINEN 100MG, Lasitace 5 mg/40 mg KapselnCategories: Non Potassium Sparing DiureticsCD44 antigen
go.drugbank.com/bio_entities/BE0001113TargetHumansCell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates...
Synonyms: PGP-I, HUTCH-IMenadione
go.drugbank.com/drugs/DB00170ApprovedNutraceuticalA synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Synonyms: Vitamin K 3, 2-Methyl-1,4-naphthochinonMixtures: LIBAVIT-K 20 MG AMPUL, 5 ADETFerumoxytol
go.drugbank.com/drugs/DB06215ApprovedInvestigational[L54506] It is comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate shell in an isotonic, neutral pH solution that may be administered at relatively … Ferumoxytol is an intravenously administered iron preparation previously indicated in the EU and the US for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD) [
Categories: Compounds used in a research, industrial, or household settingSynonyms: Ferumoxytol non-stoichiometric magnetiteCorrinoid adenosyltransferase MMAB
go.drugbank.com/bio_entities/BE0000456EnzymeHumansConverts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion (PubMed:12514191).
Synonyms: ATP:co(I)rrinoid adenosyltransferase MMABInosine-5'-monophosphate dehydrogenase 1
go.drugbank.com/bio_entities/BE0000761TargetEnzymeHumansCatalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation ...
Synonyms: IMPDH-IGlutamine synthetase
go.drugbank.com/bio_entities/BE0001881TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
Synonyms: Glutamine synthetase I beta