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Displaying results 1111 - 1120 of 10000 in total
  1. Target

    Vasoactive intestinal polypeptide receptor 1

    go.drugbank.com/bio_entities/BE0013137
    TargetHumans

    G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed

    Polypeptides: Vasoactive intestinal polypeptide receptor 1Synonyms: VPAC1 receptor, PACAP type II receptor
  2. Target

    GDNF family receptor alpha-1

    go.drugbank.com/bio_entities/BE0013583
    TargetHumans

    GDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977)

    Polypeptides: GDNF family receptor alpha-1Synonyms: GDNF receptor alpha-1, TGF-beta-related neurotrophic factor receptor 1
  3. Target

    Corticotropin-releasing hormone receptor 2

    go.drugbank.com/bio_entities/BE0014244
    TargetHumans

    G protein-coupled receptor for CRH, UCN, UCN2 and UCN3 stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11329063, PubMed:11416224, PubMed:20966082, PubMed:22689579

    Polypeptides: Corticotropin-releasing hormone receptor 2Synonyms: Corticotropin-releasing factor receptor 2
  4. Target

    Interleukin-10 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0014391
    TargetHumans

    Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.

    Polypeptides: Interleukin-10 receptor subunit alphaSynonyms: IL-10 receptor subunit alpha, Interleukin-10 receptor subunit 1
  5. Target

    G protein-coupled receptor 68

    go.drugbank.com/bio_entities/BE0014724
    TargetHumans

    The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). … Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed

    Polypeptides: G protein-coupled receptor 68Synonyms: G protein-coupled receptor 12A, Ovarian cancer G protein-coupled receptor 1
  6. Target

    G protein-coupled receptor 84

    go.drugbank.com/bio_entities/BE0020007
    TargetHumans

    G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. … In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses

    Polypeptides: G protein-coupled receptor 84Synonyms: Inflammation-related G protein-coupled receptor EX33
  7. Drug

    Trimethoprim

    go.drugbank.com/drugs/DB00440
    ApprovedInvestigationalVet approved

    Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it … [L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of

    Mixtures: K.B. FAMATE, K.B. FAMATE SUSPENSION
  8. Drug

    Odesivimab

    go.drugbank.com/drugs/DB15900
    ApprovedInvestigational

    [A221825, A221830] A recent large-scale study elucidated that both neutralizing and Fc-mediated functions of antibodies were important for therapeutic benefit in animal models of EBOV infection. … Ebola virus (EBOV) remains an important human pathogen within the _Ebolavirus_ genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%.

  9. Drug

    Lucanthone

    go.drugbank.com/drugs/DB04967
    Investigational

    It is currently being tested as a radiation sensitizer.

  10. Drug

    Lemborexant

    go.drugbank.com/drugs/DB11951
    ApprovedInvestigational

    [L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits, but rather an inability to … Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.

    Categories: Orexin Receptor Antagonists