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Tumor necrosis factor receptor superfamily member 10B
go.drugbank.com/bio_entities/BE0003433TargetHumansReceptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 10BSynonyms: Death receptor 5, TRAIL receptor 2Tumor necrosis factor receptor superfamily member 9
go.drugbank.com/bio_entities/BE0003463TargetHumansReceptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable)
Polypeptides: Tumor necrosis factor receptor superfamily member 9Synonyms: 4-1BB ligand receptorGamma-aminobutyric acid receptor subunit gamma-3
go.drugbank.com/bio_entities/BE0003594TargetHumansGamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GA...
Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-3Synonyms: GABA(A) receptor subunit gamma-3Acetylcholine receptor subunit alpha-type unc-38
go.drugbank.com/bio_entities/BE0004925TargetCaenorhabditis elegansAlpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:15990870, PubMed:20027209, PubMed:9221782).
Polypeptides: Acetylcholine receptor subunit alpha-type unc-38Acetylcholine receptor subunit beta-type lev-1
go.drugbank.com/bio_entities/BE0004927TargetCaenorhabditis elegansNon-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine.
Polypeptides: Acetylcholine receptor subunit beta-type lev-1Calcitonin gene-related peptide type 1 receptor
go.drugbank.com/bio_entities/BE0009009TargetHumansLigand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. … G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685).
Polypeptides: Calcitonin gene-related peptide type 1 receptorSynonyms: Calcitonin receptor-like receptor, CGRP type 1 receptorReceptor-interacting serine/threonine-protein kinase 1
go.drugbank.com/bio_entities/BE0009531TargetHumansInhibits RIPK3-mediated necroptosis via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis (PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283).
Polypeptides: Receptor-interacting serine/threonine-protein kinase 1Synonyms: Receptor-interacting protein 1Receptor-interacting serine/threonine-protein kinase 4
go.drugbank.com/bio_entities/BE0009533TargetHumansRequired for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity).
Polypeptides: Receptor-interacting serine/threonine-protein kinase 4Synonyms: Ankyrin repeat domain-containing protein 3Tyrosine-protein phosphatase non-receptor type 12
go.drugbank.com/bio_entities/BE0009940TargetHumansDephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172).
Polypeptides: Tyrosine-protein phosphatase non-receptor type 12Tumor necrosis factor receptor superfamily member 6
go.drugbank.com/bio_entities/BE0010463TargetHumansReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 6Synonyms: FASLG receptor