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Displaying results 1121 - 1130 of 10000 in total
  1. Target

    Nucleoside diphosphate kinase A

    go.drugbank.com/bio_entities/BE0003106
    TargetEnzymeHumans

    May also function as a Mg(2+)-dependent 3'-5' DNA exonuclease, excising nucleotides from 3' single-stranded DNA or DNA with 3' single strand overhangs, suggesting a role in DNA nucleolytic processing ( … Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore

    Polypeptides: Nucleoside diphosphate kinase ASynonyms: NDPK A, NDP kinase A
  2. Target

    Stringent starvation protein A

    go.drugbank.com/bio_entities/BE0003260
    TargetYersinia pestis

    Polypeptides: Stringent starvation protein ASynonyms: Putative stringent starvation protein A, Regulator of transcription stringent starvation protein A
  3. Target

    Poly(A) polymerase alpha

    go.drugbank.com/bio_entities/BE0004515
    TargetHumans

    May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus … Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites.

    Polypeptides: Poly(A) polymerase alpha
  4. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0008382
    TargetEscherichia coli (strain K12)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed:12051842, PubMed:18642932, … E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB subunit is toxic in E.coli, while the E.coli copy can be expressed in S.typhimurium even though

    Polypeptides: DNA gyrase subunit A
  5. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0008385
    TargetStaphylococcus aureus

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. … Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

    Polypeptides: DNA gyrase subunit A
  6. Target

    Repulsive guidance molecule A

    go.drugbank.com/bio_entities/BE0018257
    TargetHumans

    It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8 … Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system.

    Polypeptides: Repulsive guidance molecule ASynonyms: RGM domain family member A
  7. Target

    Poly(A) polymerase gamma

    go.drugbank.com/bio_entities/BE0018981
    TargetHumans

    Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA

    Polypeptides: Poly(A) polymerase gammaSynonyms: Neo-poly(A) polymerase
  8. Drug

    Witch hazel

    go.drugbank.com/drugs/DB11111
    ApprovedInvestigationalNutraceutical

    Mixtures: Hemorrhoidal Soothing Well at Walgreens, Preparation HProducts: Placenta EX Deep Line, Tone and Line Change Pack
  9. Drug

    Somatostatin

    go.drugbank.com/drugs/DB09099
    ApprovedInvestigationalWithdrawn

    [DB00104] is a long-acting analogue of somatostatin that inhibits the release of a number of hormones, and is clinically used to relieve symptoms of uncommon gastroenteropancreatic endocrine tumours, as … Somatostatin is initially secreted as a 116 amino acid precursor, preprosomatostatin, which undergoes endoproteolytic cleavage to prosomastatin.

    Mixtures: Stilamin - Pws Liq IVCategories: P-glycoprotein substrates, Cytochrome P-450 CYP3A Inhibitors
  10. Target

    Lipid A palmitoyltransferase PagP

    go.drugbank.com/bio_entities/BE0001965
    TargetEscherichia coli (strain K12)

    Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors.

    Polypeptides: Lipid A palmitoyltransferase PagPSynonyms: Lipid A acylation protein