DNA gyrase subunit A

BE0008385ProteinStaphylococcus aureusgyrA

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. It is acted on by 28 drugs in DrugBank.

Gene name
gyrA
UniProtKB entry
P20831Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
889 residues · 99,620 Da
Also known as
5.6.2.2 · 5.99.1.3

Resolves to

Protein
UniProtP20831UniProt nameGYRA_STAAU
Structure
PDB4PLBPDB5BS3
Drugs

What you can answer from here — as of September 07, 2019

28DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA gyrase subunit A, how selective are they, and which programs against it are still in active trials?

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