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Displaying results 1171 - 1180 of 10000 in total
  1. Indication

    Acute Myeloid Leukemia

    go.drugbank.com/conditions/DBCOND0029883
    Drugs: Azacitidine · Cedazuridine · Cyclophosphamide · Cytarabine · Decitabine · Doxorubicin +9 more
    Synonyms: Refractory anemia with excess blasts in transformation, Refractory anaemia with excess blasts in transformation
  2. Target

    Serine/threonine-protein kinase Nek11

    go.drugbank.com/bio_entities/BE0004758
    TargetHumans

    Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage.

    Synonyms: Never in mitosis A-related kinase 11
  3. Target

    Serine/threonine-protein kinase Nek5

    go.drugbank.com/bio_entities/BE0009499
    TargetHumans

    Synonyms: Never in mitosis A-related kinase 5
  4. Target

    Chloride anion exchanger

    go.drugbank.com/bio_entities/BE0010211
    TransporterHumans

    Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity) … Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094).

    Synonyms: Down-regulated in adenoma
  5. Target

    Serine/threonine-protein kinase Nek7

    go.drugbank.com/bio_entities/BE0017593
    TargetHumans

    Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757).

    Synonyms: Never in mitosis A-related kinase 7
  6. Drug

    Glycine

    go.drugbank.com/drugs/DB00145
    ApprovedInvestigationalNutraceuticalVet approved

    A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.

    Mixtures: Aminosyn II 7% M In 10% Dextrose(dual Chamber), Aminosyn II in DextroseProducts: GLICINA IRRIGACION 1.5% M/V, GLICINA IRRIGACION USP (1.5% W/V)BOLSA POR 3000 ML
  7. Target

    Apolipoproteins

    go.drugbank.com/bio_entities/BE0010065
    CarrierTargetHumans

    Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor … In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL

    Polypeptides: Apolipoprotein ESynonyms: Apo-E
  8. Target

    Autotaxin

    go.drugbank.com/bio_entities/BE0010333
    TargetHumans

    May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). … Involved in several motility-related processes such as angiogenesis and neurite outgrowth.

    Synonyms: E-NPP 2
  9. Drug

    Deferiprone

    go.drugbank.com/drugs/DB08826
    ApprovedInvestigational

    Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. … Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired.

    Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesSynonyms: 1,2-Dimethyl-3-hydroxypyrid-4-one, 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
  10. Drug

    Diltiazem

    go.drugbank.com/drugs/DB00343
    ApprovedInvestigational

    Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. … Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester, (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate