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Diacylglycerol O-acyltransferase 1
go.drugbank.com/bio_entities/BE0012021TargetHumansCatalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:32433610, … Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399
Synonyms: Acyl-CoA retinol O-fatty-acyltransferaseProstaglandin G/H synthase 2
go.drugbank.com/bio_entities/BE0009550TargetCanis lupus familiarisSynonyms: COX-2Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
go.drugbank.com/bio_entities/BE0000377TargetHumansMitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role i...
Synonyms: Short-chain 3-hydroxyacyl-CoA dehydrogenaseFunction: (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activityOuter membrane porin F
go.drugbank.com/bio_entities/BE0001570TargetTransporterEscherichia coli (strain K12)Forms pores that allow passive diffusion of small molecules across the outer membrane.
Synonyms: coaOuter membrane protein A
go.drugbank.com/bio_entities/BE0002043TargetEscherichia coli (strain K12)With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm (Probable). Plays a role in resistance to environmental stress, and a role in outer membrane functionality and cell shape (PubMed...
Synonyms: conCytochrome b
go.drugbank.com/bio_entities/BE0004428TargetPlasmodium falciparumComponent of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contribut...
Synonyms: COBPyridoxal phosphate homeostasis protein
go.drugbank.com/bio_entities/BE0002149TargetHumansPyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6
Synonyms: Proline synthase co-transcribed bacterial homolog proteinSerine palmitoyltransferase 2
go.drugbank.com/bio_entities/BE0000660TargetHumansThe SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA … commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851, PubMed:19648650, PubMed:20504773, PubMed:20920666).
Synonyms: Serine-palmitoyl-CoA transferase 2Cytochrome b
go.drugbank.com/bio_entities/BE0000938TargetHumansComponent of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contribut...
Synonyms: COBSerine palmitoyltransferase 3
go.drugbank.com/bio_entities/BE0002172TargetHumansThe SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA … commonly palmitoyl-CoA) to form long-chain bases (PubMed:19416851, PubMed:19648650).
Synonyms: Serine-palmitoyl-CoA transferase 3