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Mitogen-activated protein kinase 13
go.drugbank.com/bio_entities/BE0003391TargetHumansSome of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. … activation of transcription factors such as ELK1 and ATF2.
Polypeptides: Mitogen-activated protein kinase 13Synonyms: Stress-activated protein kinase 4, Mitogen-activated protein kinase p38 deltaMitogen-activated protein kinase 8
go.drugbank.com/bio_entities/BE0003790TargetHumansIn this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. … Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway (PubMed:28943315).
Polypeptides: Mitogen-activated protein kinase 8Synonyms: Stress-activated protein kinase 1c, Stress-activated protein kinase JNK15'-AMP-activated protein kinase
go.drugbank.com/bio_entities/BE0004907TargetTransporterHumansActivated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. … Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.
Polypeptides: 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit beta-2Mitogen-activated protein kinase 7
go.drugbank.com/bio_entities/BE0009477TargetHumansUpon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. … Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5.
Polypeptides: Mitogen-activated protein kinase 7Basement membrane-specific heparan sulfate proteoglycan core protein
go.drugbank.com/bio_entities/BE0001031TargetHumansComponent of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. … It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury.
Polypeptides: Basement membrane-specific heparan sulfate proteoglycan core proteinEpithelial sodium channel subunit delta
go.drugbank.com/bio_entities/BE0000495TargetHumanssodium balance and fluid homeostasis (PubMed:16423824, PubMed:19520916, PubMed:7499195). … This subunit could also function independently as a sodium channel or assemble into other tissue-specific heterotrimeric sodium channels (PubMed:7499195)
Polypeptides: Epithelial sodium channel subunit deltaSynonyms: Amiloride-sensitive sodium channel subunit delta, Nonvoltage-gated sodium channel 1 subunit deltaSodium-dependent organic anion transporter
go.drugbank.com/bio_entities/BE0004710TransporterHumansCan also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (PubMed:17491011) … Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (PubMed:23667501, PubMed:24717977).
Polypeptides: Sodium-dependent organic anion transporterSodium-dependent phosphate transporter 1
go.drugbank.com/bio_entities/BE0005055TransporterHumansMay play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). … Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632,
Polypeptides: Sodium-dependent phosphate transporter 1Sodium-dependent phosphate transporter 2
go.drugbank.com/bio_entities/BE0008680TransporterHumansPlays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). … Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity)
Polypeptides: Sodium-dependent phosphate transporter 2P-type sodium-transporting ATPase4
go.drugbank.com/bio_entities/BE0009185TargetPlasmodium falciparum (isolate 3D7)Sodium-exporting ATPase (PubMed:23414762, PubMed:29986883, PubMed:31311978, PubMed:36180431).
Polypeptides: P-type sodium-transporting ATPase4Function: ABC-type sodium transporter activity