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Displaying results 111 - 120 of 134107 in total
  1. Pathway

    Morphine Metabolism Pathway

    smpdb.ca/view/SMP0000622
    Drug metabolism

    G(i) also activates potassium channels and inactivates calcium channels causing the neuron to hyperpolarize. … The end result is decreased nerve conduction and reduced neurotransmitter release, which blocks the perception of pain signals.

    Drugs: Morphine · Uridine-5'-Diphosphate
    Enzymes: Protein disulfide-isomerase A4, Protein disulfide-isomerase A2
  2. Pathway

    Etoposide Metabolism Pathway

    smpdb.ca/view/SMP0000601
    Drug metabolism

    It is used to treat many types of cancers, including nonlymphocytic leukemia and testicular cancer. Etoposide is semisynthetic and a derivative of the podophyllotoxins which is an epipodophyllotoxin. … This breaks the catalytic cycle of topoisomerase II, and after a while overwhelms the cell. This can cause a death pathway, killing the cancer cell.

    Drugs: NADH · ATP · Etoposide · Calcium · Magnesium cation · Mesoheme +2 more
    Enzymes: Protein disulfide-isomerase A4, Protein disulfide-isomerase A2
  3. Pathway

    Etoposide Action Pathway

    smpdb.ca/view/SMP0000442
    Drug action

    It is used to treat many types of cancers, including nonlymphocytic leukemia and testicular cancer. Etoposide is semisynthetic and a derivative of the podophyllotoxins which is an epipodophyllotoxin. … This breaks the catalytic cycle of topoisomerase II, and after a while overwhelms the cell. This can cause a death pathway, killing the cancer cell.

    Drugs: NADH · ATP · Etoposide · Calcium · Magnesium cation · Mesoheme +2 more
    Enzymes: Protein disulfide-isomerase A4, Protein disulfide-isomerase A2
  4. Pathway

    Androstenedione Metabolism

    smpdb.ca/view/SMP0030406
    Metabolic

    Androstenedione is an endogenous weak androgen steroid hormone that is a precursor of testosterone and other androgens, as well as of estrogens like estrone . … Androstenedione can also be converted into etiocholanolone glucuronide, androsterone glucuronide, and adrenosterone.

    Drugs: NADH · Testosterone · Estrone · Androstenedione · Androstanedione · Formic acid +4 more
    Enzymes: Protein disulfide-isomerase A4, Protein disulfide-isomerase A2
  5. Pathway

    Ibuprofen Metabolism Pathway

    smpdb.ca/view/SMP0000590
    Drug metabolism

    These enzymes are available as COX1 and COX2, and are encoded by PTGS1 (COX1) and PTGS2 (COX2). … Ibuprofen is a very common NSAID drug used to treat pain and inflammation. This includes headaches, muscle pain and fever. It is sold under the brand name Advil or Motrin.

    Drugs: Ibuprofen · Mesoheme · Uridine-5'-Diphosphate
    Enzymes: Protein disulfide-isomerase A4, Protein disulfide-isomerase A2
  6. Pathway

    Irinotecan Action Pathway

    smpdb.ca/view/SMP0000433
    Drug action

    Specifically cancers of the rectum and of the colon. Commonly used in combination with chemotherapy. … Irinotecan is a medication commonly sold as Camptosar, used to stop the growth of cancer cells, and to stop the spread of cancer cells in the human body.

    Drugs: ATP · Irinotecan · Mesoheme · Uridine-5'-Diphosphate · SN-38
    Enzymes: Protein disulfide-isomerase A4, Protein disulfide-isomerase A2
  7. Pathway

    Irinotecan Metabolism Pathway

    smpdb.ca/view/SMP0000600
    Drug metabolism

    Specifically cancers of the rectum and of the colon. Commonly used in combination with chemotherapy. … Irinotecan is a medication commonly sold as Camptosar, used to stop the growth of cancer cells, and to stop the spread of cancer cells in the human body.

    Drugs: ATP · Irinotecan · Mesoheme · Uridine-5'-Diphosphate · SN-38
    Enzymes: Protein disulfide-isomerase A4, Protein disulfide-isomerase A2
  8. Pathway

    Acetaminophen Metabolism Pathway

    smpdb.ca/view/SMP0000640
    Drug metabolism

    Glucuronidation is the main route, accounting for 45-55% of APAP metabolism, and is mediatied by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver and UGT1A10 in the gut. … In the liver, this step is catalyzed by the sulfotransferases SULT1A1, SULT1A3, SULT1A4, SULT1E1 and SULT2A1.

    Drugs: Glutathione · NADH · ATP · Acetaminophen · Mesoheme · Uridine-5'-Diphosphate
    Enzymes: Protein disulfide-isomerase A4, Protein disulfide-isomerase A2
  9. Pathway

    Retinol Metabolism

    smpdb.ca/view/SMP0000074
    Metabolic

    Retinol is part of the vitamin A family, and is known as vitamin A1, and in a dietary context it is a type of preformed vitamin A. … Additionally, herbivores and omnivores can obtain provitamin A from things such as alpha-, beta- and gamma-carotene, which can be converted to retinol as needed by the body.

    Drugs: NADH · Vitamin A · Alitretinoin · Tretinoin · Iron · Zinc +2 more
    Enzymes: Protein disulfide-isomerase A4, Protein disulfide-isomerase A2
  10. Pathway

    Vitamin A Deficiency

    smpdb.ca/view/SMP0125788
    Disease

    A defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair. … Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two substrates are beta-carotene and O2, whereas its product is retinal.

    Drugs: NADH · Vitamin A · Alitretinoin · Tretinoin · Iron · Zinc +2 more
    Enzymes: Protein disulfide-isomerase A4, Protein disulfide-isomerase A2