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Displaying results 111 - 120 of 682 in total
  1. Drug

    Ixekizumab

    go.drugbank.com/drugs/DB11569
    ApprovedInvestigational

    Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. … In particular, IL-17A has been found to be implicated in a variety of autoimmune diseases including Rheumatoid Arthritis and plaque psoriasis.

  2. Drug

    Satralizumab

    go.drugbank.com/drugs/DB15762
    ApprovedInvestigational

    [A218546,A218551] Satralizumab is thought to exert its therapeutic benefits by blocking IL-6 receptors and, subsequently, these inflammatory responses. … Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on

    Synonyms: Humanised anti-IL-6 receptor monoclonal antibody
  3. Drug

    Sarilumab

    go.drugbank.com/drugs/DB11767
    ApprovedInvestigational

    cascades of IL-6. … Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling

  4. Drug

    Secukinumab

    go.drugbank.com/drugs/DB09029
    ApprovedInvestigational

    [L39600] By blocking the actions of IL-17A, secukinumab works to inhibit the pro-inflammatory pathways that drive immune-mediated inflammatory disorders. … Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque

  5. Drug

    Ustekinumab

    go.drugbank.com/drugs/DB05679
    ApprovedInvestigational

    Ustekinumab is a fully human immunoglobulin G1 kappa monoclonal antibody that binds the shared p40 subunit of interleukin (IL)-12 and IL-23.

  6. Drug

    Dupilumab

    go.drugbank.com/drugs/DB12159
    ApprovedInvestigational

    It is also being studied in combination with another antibody that which targets IL-33.[L7225] … Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways.

  7. Drug

    Jojoba oil

    go.drugbank.com/drugs/DB14252
    Approved

    Jojoba oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

    Mixtures: OilSynonyms: Jojoba oil, Jojoba Seed Oil
  8. Drug

    Ethanol

    go.drugbank.com/drugs/DB00898
    ApprovedInvestigational

    A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in ...

    Mixtures: Adventure First Aid .5 TinProducts: Doctor Salus Hand Sanitizer, TIDL Advanced Hand Sanitizer
  9. Indication

    Tic Disorder, Combined Vocal and Multiple Motor

    go.drugbank.com/conditions/DBCOND0082267
    Drugs: Clonazepam · Clonidine · Fluphenazine · Guanfacine · Haloperidol · Olanzapine +1 more
    Synonyms: Combined Vocal and Multiple Motor Tic Disorder, Multiple Motor and Vocal Tic Disorder, Combined
  10. Drug

    Spesolimab

    go.drugbank.com/drugs/DB15626
    ApprovedInvestigational

    Spesolimab is an interleukin-36 (IL-36) receptor antagonist. … Spesolimab works by inhibiting the inflammatory signaling pathway of IL-36,[L43090] which is often overexpressed and aberrantly overactive in generalized pustular psoriasis.