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Displaying results 1191 - 1200 of 10000 in total
  1. Target

    Calcitonin gene-related peptides

    go.drugbank.com/bio_entities/BE0010233
    TargetHumans

    CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770)

    Synonyms: CGRP-I, Calcitonin gene-related peptide I
  2. Drug

    Rabies immune globulin, human

    go.drugbank.com/drugs/DB11603
    Approved

    If IMOGAM Rabies Pasteurized is not administered as recommended at the initiation of the post-exposure rabies vaccine series, it can be administered up to eight days following the first dose of the rabies … Recommendations for passive and/or active immunization after exposure to an animal suspected of having rabies have been outlined by the National Advisory Committee on Immunization (NACI), the Advisory

    Products: EQUIRAB 1000 IU/5ML IM/SC ÇÖZELTI IÇEREN FLAKON, 1 ADET, Hyperrab S/d
  3. Drug

    Diphenylpyraline

    go.drugbank.com/drugs/DB01146
    Approved

    Antihistamines prevent, but do not reverse, responses mediated by histamine alone. … Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells.

    Synonyms: 4-(benzhydryloxy)-N-methylpiperidine, 1-methyl-4-piperidyl benzhydryl etherMixtures: Emercreme No4 Ont Efa, Emercidin D Tab
  4. Drug

    Larotrectinib

    go.drugbank.com/drugs/DB14723
    ApprovedInvestigational

    Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays … It was notable for being the second tissue-agnostic chemotherapy ever approved by the FDA.[L4847]. On April 10, 2025, the FDA granted full drug approval.[L52805]

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: VITRAKVI®CÁPSULAS DE 100MG
  5. Target

    Apolipoproteins

    go.drugbank.com/bio_entities/BE0010065
    CarrierTargetHumans

    Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. … As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins

    Polypeptides: Apolipoprotein A-ISynonyms: ApoA-I, ApoL-I
  6. Drug

    Catumaxomab

    go.drugbank.com/drugs/DB06607
    ApprovedWithdrawn

    Catumaxumab was initially authorized for market by the European Medicines Agency in April 2009 for the treatment of malignant ascites [L1122]. … Its market authorization was withdrawn in the EU in June 2017 at the manufacturer's request due to the company's insolvency.

  7. Target

    Annexin A2

    go.drugbank.com/bio_entities/BE0001170
    TargetHumans

    Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed

    Synonyms: Protein I, Calpactin I heavy chain
  8. Drug

    Mevonlerbart

    go.drugbank.com/drugs/DB19416
    Investigational

    Mevonlerbart is under investigation in clinical trial NCT06602726 (A Study to Demonstrate How Well REGN1908-1909 Works in Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Cat Allergy

    Synonyms: Anti-cat allergen fel d 1 monoclonal anitbody regn-1909, immunoglobulin G4-kappa, anti-[Fel d 1 (Felis silvestris catus (domestic cat) allergen 1)], Homo sapiens monoclonal antibody
  9. Drug

    Tebipenem pivoxil

    go.drugbank.com/drugs/DB16840
    Approved

    [L57979,L57980] It retains activity against many extended-spectrum beta-lactamase producers but not against organisms producing serine or metallo-carbapenemases. … [L57980] Tebipenem pivoxil is the first oral carbapenem approved in the United States, creating an outpatient option for patients who have limited or no alternative oral therapy.

    Categories: MATE 1 Substrates, MATE 2 Substrates
  10. Drug

    Norfloxacin

    go.drugbank.com/drugs/DB01059
    ApprovedInvestigational

    A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.

    Synonyms: 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsäure, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acidCategories: Topoisomerase II Inhibitors, 4-Quinolones