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Catumaxomab
go.drugbank.com/drugs/DB06607ApprovedWithdrawnCatumaxumab was initially authorized for market by the European Medicines Agency in April 2009 for the treatment of malignant ascites [L1122]. … Its market authorization was withdrawn in the EU in June 2017 at the manufacturer's request due to the company's insolvency.
Annexin A2
go.drugbank.com/bio_entities/BE0001170TargetHumansInhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed
Synonyms: Protein I, Calpactin I heavy chainMevonlerbart
go.drugbank.com/drugs/DB19416InvestigationalMevonlerbart is under investigation in clinical trial NCT06602726 (A Study to Demonstrate How Well REGN1908-1909 Works in Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Cat Allergy
Synonyms: Anti-cat allergen fel d 1 monoclonal anitbody regn-1909, immunoglobulin G4-kappa, anti-[Fel d 1 (Felis silvestris catus (domestic cat) allergen 1)], Homo sapiens monoclonal antibodyTebipenem pivoxil
go.drugbank.com/drugs/DB16840Approved[L57979,L57980] It retains activity against many extended-spectrum beta-lactamase producers but not against organisms producing serine or metallo-carbapenemases. … [L57980] Tebipenem pivoxil is the first oral carbapenem approved in the United States, creating an outpatient option for patients who have limited or no alternative oral therapy.
Categories: MATE 1 Substrates, MATE 2 SubstratesNorfloxacin
go.drugbank.com/drugs/DB01059ApprovedInvestigationalA synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Categories: Topoisomerase II Inhibitors, 4-QuinolonesSynonyms: 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsäure, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acidMethyltestosterone
go.drugbank.com/drugs/DB06710ApprovedInvestigationalAlso, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. … A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies.
Categories: 3-Oxoandrosten (4) Derivatives, Cytochrome P-450 SubstratesSynonyms: 17-beta-Hydroxy-17-methylandrost-4-en-3-one, 17alpha-Methyl-3-oxo-4-androsten-17beta-olSarecycline
go.drugbank.com/drugs/DB12035ApprovedInvestigationalSarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 … The acne often presents physically as a mixture of non-inflammatory and inflammatory lesions mainly on the face but on the back and chest as well [L4814].
Categories: P-glycoprotein inhibitorsNuclear cap-binding protein subunit 2
go.drugbank.com/bio_entities/BE0013483TargetHumansIn the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding … The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound
Polypeptides: Nuclear cap-binding protein subunit 2Synonyms: 20 kDa nuclear cap-binding proteinNuclear cap-binding protein subunit 1
go.drugbank.com/bio_entities/BE0014101TargetHumanscap-binding state with the cap structure. … The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound
Polypeptides: Nuclear cap-binding protein subunit 1Synonyms: 80 kDa nuclear cap-binding proteinCefdinir
go.drugbank.com/drugs/DB00535ApprovedInvestigationalCefdinir was approved by the FDA in 1997 to treat a variety of mild to moderate infections and was initially marketed by Abbvie. … It has been proven to be effective for the treatment of common bacterial infections in the ear, sinus, throat, lungs, and skin.
Synonyms: (6R,7R,Z)-7-(2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid, (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acidInternational brands: Xi Fu Ni, Omnicef R