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  1. Drug

    Elasomeran

    go.drugbank.com/drugs/DB15654
    ApprovedInvestigational

    The Moderna COVID-19 Vaccine (mRNA-1273; Elasomeran) is a novel mRNA-based vaccine encapsulated in a lipid nanoparticle that encodes for a full-length pre-fusion stabilized spike (S) protein of severe … [L28026] A phase I, open-label, dose-ranging clinical trial (NCT04283461) was initiated in March 2020 in which 45 subjects received two intramuscular doses (on days 1 and 29).

    Mixtures: Spikevax Bivalent (original / Omicron Ba.4/5)Synonyms: MRNA-1273 SARS-COV-2
  2. Drug

    Fidanacogene elaparvovec

    go.drugbank.com/drugs/DB16783
    ApprovedInvestigational

    [L49469] This approval was based on positive results demonstrated in the open-label, single-arm Phase 3 BENEGENE-2 study, where the annualized bleeding rate (ABR) was observed to be 1.3 for the 12 months … Fidanacogene elaparvovec is a liver-specific adeno-associated virus (AAV) vector containing a codon-optimized human coagulation FIX gene that was investigated as a potential treatment for hemophilia B.

  3. Drug

    Dicyclomine

    go.drugbank.com/drugs/DB00804
    ApprovedInvestigational

    [A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable. … Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder

    Synonyms: 2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarboxylate, Bicyclohexyl-1-carboxylic acid 2-diethylamino-ethyl esterMixtures: AXCEL DICYCLOMINE-S SYRUP
  4. Drug

    Betaine

    go.drugbank.com/drugs/DB06756
    ApprovedInvestigationalNutraceutical

    Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine. … It is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and maintaining cell function.

    Mixtures: KORDEL`S NUTRITIME TABLET, Ultr F/b E.S. Mega Lipotropic Fmla W B6betSynonyms: 2-N,N,N-trimethylammonio acetate, N,N,N-Trimethylglycine
  5. Drug

    Sorbitol

    go.drugbank.com/drugs/DB01638
    ApprovedInvestigational

    It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. … A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose.

    Mixtures: MINICA S ENEMA, Cystosol W 3% HexitolsCategories: Compounds used in a research, industrial, or household setting
  6. Drug

    Simvastatin

    go.drugbank.com/drugs/DB00641
    ApprovedInvestigational

    Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. … as well as the need for surgical revascularization or angioplasty following a heart attack.

    Mixtures: TIAZOMET S®, TIAZOMET S®Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  7. Drug

    Phenserine

    go.drugbank.com/drugs/DB04892
    Investigational

    If this is substantiated in an ongoing clinical trial then phenserine may open the door to an entirely new type of treatment for AD. … Phenserine is under development by Axonyx, a US biopharmaceutical company that focuses on treatments for dementia.

    Categories: Heterocyclic Compounds, 2-Ring
  8. Drug

    Anthoxanthum odoratum pollen

    go.drugbank.com/drugs/DB10404
    Approved

    Anthoxanthum odoratum pollen is the pollen of the Anthoxanthum odoratum plant. Anthoxanthum odoratum pollen is mainly used in allergenic testing.

    Mixtures: T-O-S Standardized Grass Pollen Mix, T-O-S Standardized Grass Pollen Mix
  9. Drug

    Picrotoxin

    go.drugbank.com/drugs/DB00466
    Experimental

    Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. [PubChem] … A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the gamma-aminobutyric acid-activated chloride ionophore.

    Categories: GABA-A Receptor Antagonists, Compounds used in a research, industrial, or household setting
  10. Drug

    Bupivacaine

    go.drugbank.com/drugs/DB00297
    ApprovedInvestigational

    Bupivacaine is a widely used local anesthetic agent.

    Mixtures: Mlp A-2, Mlp A-1Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates