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Displaying results 1201 - 1210 of 10000 in total
  1. Drug

    Sarecycline

    go.drugbank.com/drugs/DB12035
    ApprovedInvestigational

    Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 … The acne often presents physically as a mixture of non-inflammatory and inflammatory lesions mainly on the face but on the back and chest as well [L4814].

    Categories: P-glycoprotein inhibitors
  2. Target

    Nuclear cap-binding protein subunit 2

    go.drugbank.com/bio_entities/BE0013483
    TargetHumans

    In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding … The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound

    Polypeptides: Nuclear cap-binding protein subunit 2Synonyms: 20 kDa nuclear cap-binding protein
  3. Target

    Nuclear cap-binding protein subunit 1

    go.drugbank.com/bio_entities/BE0014101
    TargetHumans

    cap-binding state with the cap structure. … The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound

    Polypeptides: Nuclear cap-binding protein subunit 1Synonyms: 80 kDa nuclear cap-binding protein
  4. Drug

    Cefdinir

    go.drugbank.com/drugs/DB00535
    ApprovedInvestigational

    Cefdinir was approved by the FDA in 1997 to treat a variety of mild to moderate infections and was initially marketed by Abbvie. … It has been proven to be effective for the treatment of common bacterial infections in the ear, sinus, throat, lungs, and skin.

    Synonyms: (6R,7R,Z)-7-(2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid, (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acidInternational brands: Xi Fu Ni, Omnicef R
  5. Drug

    Pholcodine

    go.drugbank.com/drugs/DB09209
    ApprovedIllicit

    [A31742] Pholcodine is not prescribed in the United States where it is classed as a Schedule I drug. It is categorized as Class B drug in the UK and officially taken out of the shelves in 2008. … Pholcodine formula is 3-o-morpholinoethylmorphine and it is classified as an antitussive which is defined as an opioid cough suppressant.

    Mixtures: Rhynacol F SyrupCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds with 4 or More Rings
  6. Drug

    Rolapitant

    go.drugbank.com/drugs/DB09291
    ApprovedInvestigational

    By blocking Substance P from interacting with NK-1 receptors in the gut and the central nervous system, rolapitant prevents late-phase CINV. … Unlike other available NK-1 receptor antagonists, rolapitant is not an inhibitor of Cytochrome P450 enzyme CYP3A4 and has a long elimination half-life, allowing a single dose to prevent both acute and

    Categories: Substance P/Neurokinin-1 Receptor Antagonist, Neurokinin 1 Antagonists
  7. Drug

    Telotristat ethyl

    go.drugbank.com/drugs/DB12095
    Approved

    [L43367] Overexposure to serotonin can cause severe diarrhea, one of the main clinical symptoms of carcinoid syndrome. … [A252937] The first line treatment of carcinoid syndrome diarrhea is SSA, but symptoms still reoccur over the course of the disease.[A252937]

    Categories: Cytochrome P-450 CYP2B6 Inducers, P-glycoprotein inhibitors
  8. Drug

    Betaine

    go.drugbank.com/drugs/DB06756
    ApprovedInvestigationalNutraceutical

    However, in order to normalize homocysteine levels, patients can be treated with vitamin B6 ([pyridoxine]), vitamin B12 ([cobalamin]), [folate] and specific diets. … Currently, no treatments are available to correct the genetic causes of homocystinuria.

    Mixtures: Neo Life Beta Gest Tab, Alka-pan TabletsSynonyms: 2-N,N,N-trimethylammonio acetate, N,N,N-Trimethylglycine
  9. Target

    DNA topoisomerase 1

    go.drugbank.com/bio_entities/BE0001950
    TargetEscherichia coli (strain K12)

    Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transester...

    Synonyms: DNA topoisomerase I
  10. Target

    Cytochrome c oxidase subunit 1-beta

    go.drugbank.com/bio_entities/BE0004162
    TargetParacoccus denitrificans

    Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

    Synonyms: Cytochrome c oxidase polypeptide I-beta