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Displaying results 1201 - 1210 of 10000 in total
  1. Drug

    Lonafarnib

    go.drugbank.com/drugs/DB06448
    ApprovedInvestigational

    [A224379, A224384, A224389, A224394, A224399] Mechanistically, HGPS is underpinned by a single heterozygous C-to-T mutation at position 1824 of the _LMNA_ gene, which results in the accumulation of an … aberrant farnesylated form of lamin A called progerin in the inner nuclear membrane.

  2. Drug

    Volanesorsen

    go.drugbank.com/drugs/DB15067
    Approved

    [L16621] This drug is not commonly prescribed as it is used as an adjunct to diet in patients at high risk for pancreatitis, who have had inadequate response to triglyceride lowering therapy. … Volanesorsen is an antisense oligonucleotide that binds to apoC-III mRNA to prevent its translation.

  3. Drug

    Phenoxyethanol

    go.drugbank.com/drugs/DB11304
    ApprovedInvestigational

    It is a glycol ether used as a perfume fixative, insect repellent, antiseptic, solvent, preservative, and also as an anesthetic in fish aquaculture. … Phenoxyethanol is a colorless liquid with a pleasant odor.

    Mixtures: Linola sept 1 mg/g + 20 mg/g Wund-Spray zur Anwendung auf der Haut, Lösung
  4. Target

    Vascular endothelial growth factor receptor 3

    go.drugbank.com/bio_entities/BE0000023
    TargetHumans

    The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. … Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular

    Polypeptides: Vascular endothelial growth factor receptor 3Synonyms: Tyrosine-protein kinase receptor FLT4
  5. Target

    Receptor-type tyrosine-protein kinase FLT3

    go.drugbank.com/bio_entities/BE0000147
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells.

    Polypeptides: Receptor-type tyrosine-protein kinase FLT3Synonyms: FL cytokine receptor
  6. Target

    Sigma non-opioid intracellular receptor 1

    go.drugbank.com/bio_entities/BE0000290
    TargetHumans

    Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the...

    Polypeptides: Sigma non-opioid intracellular receptor 1Synonyms: Sigma 1-type opioid receptor, Sigma non-opioid intracellular receptor 1
  7. Target

    Vascular endothelial growth factor receptor 2

    go.drugbank.com/bio_entities/BE0000369
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD.

    Polypeptides: Vascular endothelial growth factor receptor 2Synonyms: Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1
  8. Target

    Taste receptor type 1 member 2

    go.drugbank.com/bio_entities/BE0000395
    TargetHumans

    Key component of the sweet taste receptor (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). … Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580)

    Polypeptides: Taste receptor type 1 member 2Synonyms: Sweet taste receptor T1R2, G protein-coupled receptor 71
  9. Target

    Neuronal acetylcholine receptor subunit beta-2

    go.drugbank.com/bio_entities/BE0000850
    TargetHumans

    Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...

    Polypeptides: Neuronal acetylcholine receptor subunit beta-2
  10. Target

    Platelet-derived growth factor receptor alpha

    go.drugbank.com/bio_entities/BE0000852
    TargetEnzymeHumans

    Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis

    Polypeptides: Platelet-derived growth factor receptor alphaSynonyms: Alpha platelet-derived growth factor receptor, Platelet-derived growth factor receptor 2