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Displaying results 1231 - 1240 of 10000 in total
  1. Drug

    Midecamycin

    go.drugbank.com/drugs/DB13456
    Investigational

    In this molecule, an acetoxy group is substituted on the position 9 of the 16-member ring and on position 4 of the terminal sugar. … Midecamycin is a naturally occurring 16-membered macrolide [A33072] that fits under the category of acetoxy-substituted macrolide antibiotics.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSynonyms: Espinomycin A
  2. Drug

    Phenaridine

    go.drugbank.com/drugs/DB09178
    ExperimentalIllicit

    Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue … Phenaridine (2,5-Dimethylfentanyl) is a synthetic fentanyl derivative opioid. It was developed in 1972, and is used for surgical anasthesia in Russia. Phenaridine has similar effects to fentanyl.

    Categories: Heterocyclic Compounds, 1-Ring
  3. Drug

    Tepotinib

    go.drugbank.com/drugs/DB15133
    ApprovedInvestigational

    In February 2022, tepotinib was approved for use in Europe.[L42200] … Tepotinib is a MET tyrosine kinase inhibitor intended to treat a variety of MET-overexpressing solid tumors.

    Categories: MATE 1 Inhibitors, MATE 2 Inhibitors
  4. Pathway

    Gs Serotonergic Smooth Muscle Contraction

    smpdb.ca/view/SMP0127045
    Physiological

    Serotonergic (5-HT4) receptors are typically coupled to Gs proteins. Activation of Gs proteins stimulates adenylate cyclase (AC), leading to increased production of cyclic AMP (cAMP) from ATP.Gs proteins stimulate adenylate cyclase (AC) ...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  5. Drug

    Linaclotide

    go.drugbank.com/drugs/DB08890
    ApprovedInvestigational

    Linaclotide is a synthetic 14-amino acid cyclic peptide [A260271] and first-in-class guanylate cyclase-C (G-CC) agonist. … [A260276] It is also a homolog of a heat-stable enterotoxin derived from _Escherichia coli_, the first natural ligand that activates GC-C.

    Categories: Guanylate Cyclase-C Agonist, Guanylyl Cyclase C AgonistsSynonyms: -GLUTAMYL-L-TYROSYL-L-CYSTEINYL-L-CYSTEINYL-L-ASPARAGINYL-L-PROLYL-L-ALANYL-L-CYSTEINYL-L-THREONYLGLYCYL-L-CYSTEINYL-, CYCLIC (1->6),(2->10),(5->13)-TRIS(DISULFIDE), L-TYROSINE, L-CYSTEINYL-L-CYSTEINYL-L-.ALPHA.
  6. Drug

    Flax seed

    go.drugbank.com/drugs/DB10708
    Approved

    Flax seed allergenic extract is used in allergenic testing.

    Mixtures: Nature"s Gift CoQ10 Plus
  7. Pathway

    Gi Serotonergic Smooth Muscle Relaxation

    smpdb.ca/view/SMP0126986
    Physiological

    Although numerous GPCRs have the ability to couple to more than one heterotrimeric G protein, a given GPCR is typically classified based on the G protein subfamily (e.g., Gs, Gi/o, or Gq/11) it preferentially activates. Activation of the...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  8. Pathway

    Metoclopramide Serotonergic Smooth Muscle Contraction

    smpdb.ca/view/SMP0127039
    Drug action

    Metoclopramide is a dopamine receptor antagonist and has been approved by the FDA to treat nausea and vomiting in patients with gastroesophageal reflux disease or diabetic gastroparesis by increasing gastric motility.. Metoclopramide wor...

    Drugs: ATP · Metoclopramide · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +1 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  9. Pathway

    Prucalopride Action Pathway

    smpdb.ca/view/SMP0127044
    Drug action

    Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs. 5-HT4 receptors can be ...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid +1 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  10. Drug

    Rutin

    go.drugbank.com/drugs/DB01698
    ApprovedInvestigational

    A flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility.

    Mixtures: KORDEL`S C TIME ACID FREE C 1000MG TABLET, KORDEL`S NUTRITIME TABLETCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 Inducers