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Multidrug and toxin extrusion protein 1
go.drugbank.com/bio_entities/BE0003657TransporterEnzymeTargetHumansPlays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed … Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230,
Polypeptides: Multidrug and toxin extrusion protein 1Sodium- and chloride-dependent betaine transporter
go.drugbank.com/bio_entities/BE0004777TargetTransporterHumansTransporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). … Probably also involved in renal and hepatic osmotic regulation (By similarity)
Polypeptides: Sodium- and chloride-dependent betaine transporterHyaluronan and proteoglycan link protein 1
go.drugbank.com/bio_entities/BE0004933TargetHumansStabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix
Polypeptides: Hyaluronan and proteoglycan link protein 1Hyaluronan and proteoglycan link protein 3
go.drugbank.com/bio_entities/BE0004935TargetHumansMay function in hyaluronic acid binding
Polypeptides: Hyaluronan and proteoglycan link protein 3Calcium and integrin-binding protein 1
go.drugbank.com/bio_entities/BE0008691TargetHumansForms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (PubMed:30068544, PubMed:32917726) … Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.
Polypeptides: Calcium and integrin-binding protein 1Synonyms: Calcium- and integrin-binding proteinFluvoxamine
go.drugbank.com/drugs/DB00176ApprovedInvestigationalIt was launched in the US in December 1994 and in Japan in June 1999. As of the end of 1995, more than 10 million patients worldwide have been treated with fluvoxamine. … Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
Categories: Metabolic Side Effects of Drugs and SubstancesProducts: FEVARIN 100MG, Gen-fluvoxamine 100mgPhenylbutazone
go.drugbank.com/drugs/DB00812ApprovedVet approvedWithdrawn(From AMA Drug Evaluations Annual, 1994, p1822) … It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication).
Categories: phenylbutazone and corticosteroids, Antiinflammatory and Antirheumatic ProductsProducts: Novo-butazone Tab 100mg, Apo Phenylbutazone Tab 100mgSatralizumab
go.drugbank.com/drugs/DB15762ApprovedInvestigationaloccurs in a pH-dependent manner[A218551] - this allows satralizumab to bind an IL-6 receptor until it reaches an endosome, after which the drug may dissociate from the receptor and move back into the … [A218551] It received subsequent approvals in Switzerland and Japan,[A218551] and was approved for use by the FDA in August 2020,[L15566] becoming the 3rd treatment to receive FDA approval for NMOSD (after
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: ENSPRYNG® SATRALIZUMAB 120MG/ML, ENSPRYNG SOLUTION FOR INJECTION IN PREFILLED SYRINGE 120MG/1MLAcetylcholine
go.drugbank.com/drugs/DB03128ApprovedInvestigationalIt is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications. … Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in
Categories: Antiglaucoma Preparations and MioticsProducts: Miogan Pws 20mg/vialErenumab
go.drugbank.com/drugs/DB14039ApprovedInvestigationalAimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the first and only FDA approved treatment specifically developed to prevent migraine by blocking the … It is composed of 2 heavy chains, each containing 456 amino acids, and 2 light chains of the lambda subclass, each containing 216 amino acids, with an approximate molecular weight of 150 kDa [FDA Label
Categories: Amino Acids, Peptides, and ProteinsProducts: AIMOVIG SOLUTION FOR INJECTION IN PRE-FILLED PEN 140MG/ML, AIMOVIG SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 140MG/ML