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Displaying results 1231 - 1240 of 10000 in total
  1. Drug

    Benzocaine

    go.drugbank.com/drugs/DB01086
    ApprovedInvestigational

    [A231219] It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.[A231259] … Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

    Mixtures: CARMEX Multi-Symptom 3 in 1 COLD Sore treatment External Analgesic Skin Protectant, E-Vac PlusCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  2. Target

    Nuclear factor NF-kappa-B p105 subunit

    go.drugbank.com/bio_entities/BE0001086
    TargetHumans

    NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. … the enhancer region of genes involved in immune response and acute phase reactions.

    Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  3. Target

    Inhibitor of nuclear factor kappa-B kinase subunit epsilon

    go.drugbank.com/bio_entities/BE0009450
    TargetHumans

    Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (By similarity). … Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling (PubMed:18583960, PubMed:19153231, PubMed:22532683, PubMed:23478265).

    Synonyms: IKK-E
  4. Target

    Retinal guanylyl cyclase 1

    go.drugbank.com/bio_entities/BE0013774
    TargetHumans

    Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. … May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (By similarity)

    Synonyms: CG-E
  5. Drug

    Magnesium chloride

    go.drugbank.com/drugs/DB09407
    ApprovedInvestigational

    Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water.

    Mixtures: Isolyte H in Dextrose, Isolyte P in Dextrose
  6. Target

    Low affinity immunoglobulin epsilon Fc receptor

    go.drugbank.com/bio_entities/BE0003465
    TargetHumans

    Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells.

    Synonyms: Immunoglobulin E-binding factor
  7. Drug

    Candesartan cilexetil

    go.drugbank.com/drugs/DB00796
    ApprovedInvestigational

    It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. … Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension.

    Mixtures: CANDESARTAN E IDROCLOROTIAZIDE EG, CANDESARTAN E IDROCLOROTIAZIDE EGCategories: Angiotensin II receptor antagonists, Angiotensin II Antagonists and Diuretics
  8. Target

    Nuclear factor NF-kappa-B complex

    go.drugbank.com/bio_entities/BE0009554
    TargetHumans

    NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. … NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family.

    Synonyms: Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  9. Drug

    Hydroxyzine

    go.drugbank.com/drugs/DB00557
    ApprovedInvestigational

    [A1257,A187589] It was first developed in 1955,[A189726] and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus … Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.

    Mixtures: DOLMARAL®Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  10. Target

    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    go.drugbank.com/bio_entities/BE0005530
    TargetHumans

    Involved in the regulation of synaptic function in excitatory hippocampal synapses. … May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.

    Synonyms: Mutated in multiple advanced cancers 1