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Scavenger receptor cysteine-rich type 1 protein M130
go.drugbank.com/bio_entities/BE0003375TargetHumansMay play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. … Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage.
Polypeptides: Scavenger receptor cysteine-rich type 1 protein M130Synonyms: Hemoglobin scavenger receptorPutative high affinity immunoglobulin gamma Fc receptor IB
go.drugbank.com/bio_entities/BE0004684TargetHumansMay bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response
Polypeptides: Putative high affinity immunoglobulin gamma Fc receptor IBSynonyms: IgG Fc receptor IB, Fc gamma receptor IB pseudogeneNuclear receptor subfamily 4 group A member 3
go.drugbank.com/bio_entities/BE0008998TargetHumansIn mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity).
Polypeptides: Nuclear receptor subfamily 4 group A member 3Synonyms: Nuclear hormone receptor NOR-1, Neuron-derived orphan receptor 1Nuclear receptor subfamily 1 group D member 2
go.drugbank.com/bio_entities/BE0009348TargetHumansActs as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. … Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN.
Polypeptides: Nuclear receptor subfamily 1 group D member 2Synonyms: Rev-erb alpha-related receptor, Orphan nuclear hormone receptor BD73Leukocyte immunoglobulin-like receptor subfamily A member 4
go.drugbank.com/bio_entities/BE0013620TargetHumansFunctions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354).
Polypeptides: Leukocyte immunoglobulin-like receptor subfamily A member 4Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
go.drugbank.com/bio_entities/BE0020703TargetHumansGreatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232).
Polypeptides: Peroxisome proliferator-activated receptor gamma coactivator 1-alphaRacemethionine
go.drugbank.com/drugs/DB13972ApprovedA preparation of methionine that includes a mixture of D-methionine and L-methionine isomers.
Mixtures: Vita-vim - Tab, Vita Balance 2000Plasma protein fraction (human)
go.drugbank.com/drugs/DB13968ApprovedInvestigationalThe plasma protein fraction human (PPFh) is defined as a sterile solution of proteins composed mainly of albumin and globulin derived from human plasma. It is already reviewed under the category of biologics by the FDA where the processi...
Mixtures: UMAN SERUMProgesterone
go.drugbank.com/drugs/DB00396ApprovedInvestigationalVet approvedProgesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsAntipyrine
go.drugbank.com/drugs/DB01435ApprovedAn analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates