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Displaying results 1251 - 1260 of 10000 in total
  1. Drug

    Vincristine

    go.drugbank.com/drugs/DB00541
    ApprovedInvestigational

    Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. … because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).

    Mixtures: MEODEX®, MEODEX®Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, BSEP/ABCB11 Substrates with a Narrow Therapeutic Index
  2. Target

    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

    go.drugbank.com/bio_entities/BE0010396
    TargetHumans

    During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. … Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator

    Polypeptides: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
  3. Drug

    Tolevamer

    go.drugbank.com/drugs/DB01344
    Approved

    It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. … Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels.

    Categories: Compounds used in a research, industrial, or household settingSynonyms: poly(styrene-4-sulfonic acid)
  4. Drug

    Simethicone

    go.drugbank.com/drugs/DB09512
    ApprovedInvestigational

    [A228308] It has a favourable safety profile as it is not systemically absorbed.[A228308] Simethicone has been in use since the 1940s[A228303] but was granted FDA approval in 1952.[A228308] … Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination.

    Mixtures: M A L D I M, LIBERTRIM® SII 100 MGCategories: Compounds used in a research, industrial, or household setting
  5. Drug

    Sitagliptin

    go.drugbank.com/drugs/DB01261
    ApprovedInvestigational

    Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256 … The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255].

    Mixtures: VELMETIA LP, Sitagliptin/metformin Hydrochloride SunCategories: Drugs Used in Diabetes, Cytochrome P-450 Substrates
  6. Drug

    Prezatide copper

    go.drugbank.com/drugs/DB14683
    Investigational

    Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions [A19503]. Prezatide is used in cosmetic products for the skin and hair. … It is known to aid wound healing and its potential applications in chronic obstructive pulmonary disease and metastatic colon cancer are currently being investigated.

    Synonyms: Copper tripeptide-1Mixtures: Special Skin Care Lifting Program, Pepplus Special Skin Care Lifting Program
  7. Drug

    Valerian

    go.drugbank.com/drugs/DB13196
    Approved

    Valerian is a food ingredient permitted for direct addition to food for human consumption as a natural flavoring substance. … Valerian is extracted from a herb that is a perennial flowering plant. Valerian root is reported to have sedative and anxiolytic effects however its mechanism of action is not completely understood.

    Mixtures: Dormiphen Au Naturel, S. R. FormulaProducts: Facilite Le Sommeil - Cap 270mg, Sleep-eze V Natural Caplets
  8. Drug

    Sodium fluoride

    go.drugbank.com/drugs/DB09325
    ApprovedInvestigational

    Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as [Fluoride ion F-18]. … Now, sodium fluoride may be found in a variety of gels, varnishes, rinses, toothpaste products, and fluoride treatments provided in dental care.

    Mixtures: Fluor-a-day, Fluor-a-dayCategories: Compounds used in a research, industrial, or household setting
  9. Indication

    Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor

    go.drugbank.com/conditions/DBCOND0127089
    Drugs: Dexamethasone · Isatuximab · Pomalidomide
    Synonyms: Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor
  10. Indication

    Intermittent distinct from a patient’s usual seizure pattern, stereotypic episode Epileptic seizure

    go.drugbank.com/conditions/DBCOND0120023
    Drugs: Diazepam
    Synonyms: Intermittent distinct from a patient’s usual seizure pattern, stereotypic episode Epileptic seizure