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A disintegrin and metalloproteinase with thrombospondin motifs 5

Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN (PubMed:16133547, … Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration.

Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380)

Signal transducer and activator of transcription 1-alpha/beta

Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 … and STAT2.

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539).

Ankyrin repeat and protein kinase domain-containing protein 1

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447) … Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447).

2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530 … Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647).

General transcription and DNA repair factor IIH helicase/translocase subunit XPB

The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). … In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107).