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Coagulation
smpdb.ca/view/SMP0000586PhysiologicalIn the intrinsic, or contact, pathway, injury exposes collagen to the bloodstream where is binds to factor XII and activates it to XIIa. … Factor Xa complexes with factor Va (which functions as a non-enzymatic cofactor), calcium and a phospholipid membrane surface to form what is called the prothrombinase complex, which converts prothrombin
Enzymes: Collagen alpha-1(I) chainPhenindione Action Pathway
smpdb.ca/view/SMP0000655Drug actionPhenindione is a medication that is used as an anticoagulant. Anticoagulants are drugs that prevent the blood from coagulating and creating blood clots. … It is used to treat a variety of conditions, including cerebral and pulmonary embolisms, as well as cardiomyopathy.
Enzymes: Collagen alpha-1(I) chainFondaparinux.
smpdb.ca/view/SMP0000273Drug actionIt is also activated through plasma prekallikrein and coagulation factor XIIa which activate plasma kallikrein, which then pairs with coagulation factor XII simultaneously with the previous collagen chain … This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin and coagulation factors VII, IX and X.
Enzymes: Collagen alpha-1(I) chainHeparin.
smpdb.ca/view/SMP0000274Drug actionActivated antithrombin III will inactive prothrombin and factor Xa (also other proteases). … Heparin (also named unfractionated heparin or Clexane) is an anticoagulant medication.
Enzymes: Collagen alpha-1(I) chainEnoxaparin.
smpdb.ca/view/SMP0000272Drug actionTherefore, low molecular weight heparins like Enoxaparin are more stable and predictable heparins. … The drug increases the inactivation of coagulation factors IXa, Xa and XIIa. This increases the antithrombin effects.
Enzymes: Collagen alpha-1(I) chainArdeparin Action Pathway
smpdb.ca/view/SMP0000275Drug actionArdeparin binds and increases antithrombin III activity and inactivates thrombin, factor Xa and coagulation factors XIIa, XIa, plasmin and kallikrein to prevent clot formation. … These properties increase ardeparin's bioavailability and give a more predictable anticoagulant activity.
Enzymes: Collagen alpha-1(I) chainPeginterferon alfa-2a Action Pathway
smpdb.ca/view/SMP0125981Drug actionPeginterferon alfa-2a activate interferon alpha receptors 1 and 2 (IFNAR1 and IFNAR2) which are associated with tyrosine kinase 2 (TYK2) and JAK1 respectively. … They act through IKKa and IKKb to drive NFKB induction of genes associated with survival signals, antigen processing and presentation, and proliferation.
Drugs: Peginterferon alfa-2aEnzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2Peginterferon alfa-2b Action Pathway
smpdb.ca/view/SMP0126026Drug actionIts immunomodulatory effects are the enhancement of the phagocytic activity, the activation of NK cells, the stimulation of cytotoxic T-lymphocytes, and the upregulation of the Th1 T-helper cell subset … It is also used as an adjuvant treatment of melanoma with microscopic or gross nodal involvement within 84 days of definitive surgical resection.
Drugs: Peginterferon alfa-2bEnzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2Interferon beta-1a Action Pathway
smpdb.ca/view/SMP0126027Drug actionThey act through IKKa and IKKb to drive NFKB induction of genes associated with survival signals, antigen processing and presentation, and proliferation. … These transphosphorylate themselves and phosphorylate the IFNAR and IFNAR2c. This receptor complex also phosphorylates STAT3 homodimers.
Drugs: Interferon beta-1aEnzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2Triflusal Action Pathway (new)
smpdb.ca/view/SMP0126547Drug actionDue to the anticoagulant and antiplatelet nature, herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Triflusal is administered orally and acts as an antithrombotic anticoagulant that irreversibly inhibits cyclooxygenase-1(COX-1) also known as prostaglandin g/h synthase 1.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Mesoheme +2 moreEnzymes: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A