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Indapamide Action Pathway
smpdb.ca/view/SMP0000110Drug actionSodium-chloride symporter (also known as solute carrier family 12 member 3) can translocate chloride and sodium from lumen to epithelial cell. … Sodium-potassium ATPase can export sodium from cell to basolateral interstitium, which lead to increased osmolarity in interstitum for later water reabsorption.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-KaKidney Function
smpdb.ca/view/SMP0000483PhysiologicalBlood pressure is regulated by the hormones angiotensin II and aldosterone, which increases sodium chloride reabsorption. … Only water is reabsorbed in the thin descending loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of Henle.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-KaTriamterene Action Pathway
smpdb.ca/view/SMP0000132Drug actionThis primarily contributes to an increase in sodium excretion and consequentially, fluid excretion which decreases blood volume and blood pressure. … Potassium secretion is indirectly affected by the inhibition of sodium reabsorption due to the elimination of the electrochemical gradient that drives potassium loss.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-KaSpironolactone Action Pathway
smpdb.ca/view/SMP0000134Drug actionAldosterone increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium-potassium ATPases as well as luminal (apical) sodium and potassium channels. … Spironolactone inhibits sodium and water reabsorption as well as potassium excretion by blocking the actions of aldosterone as described above.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-KaQuinethazone Action Pathway (old)
smpdb.ca/view/SMP0000091Drug actionIn the case of quinethazone, it inhibits the sodium-chloride symporter, solute carrier family 12 member 3. Thiazides also inhibit sodium ion transport. … The short term mechanism of action is relatively well-understood: thiazides inhibit sodium-chloride co-transport into the renal distal convoluted tubule of the nephron and therefore increase fluid loss
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-KaAmiloride Action Pathway
smpdb.ca/view/SMP0000133Drug actionAmiloride causes an increase in sodium excretion and a decrease in potassium secretion. The drug is typically prescribed to patients with depleted potassium. … Therefore, amiloride's inhibition of sodium reabsorption fails to produce an electrochemical gradient and therefore, inhibits potassium excretion.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-KaEplerenone Action Pathway (Old)
smpdb.ca/view/SMP0000135Drug actionAldosterone increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium-potassium ATPases as well as luminal (apical) sodium and potassium channels. … Eplerenone inhibits sodium and water reabsorption as well as potassium excretion by blocking the actions of aldosterone as described above.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-KaHypochloremic state
go.drugbank.com/conditions/DBCOND0023348Synonyms: Other disorders of electrolyte and fluid balance, not elsewhere classifiedTorsemide Action Pathway
smpdb.ca/view/SMP0000118Drug actionThis prevents the reuptake of sodium into the Loop of Henle which consequentially reduces the uptake of water and serves to both increase water loss and reduce blood pressure. … It is commonly used to manage hypertension and edema in cases of congestive heart failure as it acts as a diuretic by blocking sodium transporters NKCC2 on the thick ascending limb of the Loop of Henle
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-KaLysinuric Protein Intolerance (LPI)
smpdb.ca/view/SMP0000585DiseaseIt is caused by a mutation in the SLC7A7 gene which encodes the Y+L amino acid transporter 1 protein, which is involved in the uptake of amino acids, both with sodium for neutral amino acids, and without … Symptoms of the disorder include failure to thrive after weaning, nausea and vomiting following a meal containing large amounts of protein, as well as osteoporosis, and lung and kidney problems.
Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka