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Displaying results 1291 - 1300 of 3888 in total
  1. Drug

    Sotagliflozin

    go.drugbank.com/drugs/DB12713
    ApprovedInvestigational

    Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind,[A244499] which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type … [A244470,A244499] Sotagliflozin was approved by the EMA under the brand name "Zynquista" on April 26, 2019, for the treatment of type 1 diabetes.

  2. Drug

    Tegafur-uracil

    go.drugbank.com/drugs/DB09327
    Approved

    [A32073] It is approved in different countries but it is not yet approved by the FDA, Health Canada or EMA.

  3. Target

    Basement membrane-specific heparan sulfate proteoglycan core protein

    go.drugbank.com/bio_entities/BE0001031
    TargetHumans

    Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It se...

    Polypeptides: Basement membrane-specific heparan sulfate proteoglycan core protein
  4. Drug

    Chondroitin sulfate

    go.drugbank.com/drugs/DB09301
    ApprovedInvestigationalNutraceutical

    [A32063] Chondroitin sulfate is sold as an OTC dietary supplement in North America and it is a prescription drug under the EMA in Europe.[A32066]

    Mixtures: X-RAY DOL, ARTROFORT(R) COMPLEX
  5. Drug

    Tilmanocept

    go.drugbank.com/drugs/DB15373
    ApprovedInvestigationalWithdrawn

    Tilmanocept is under investigation in clinical trial NCT03241446 (Pharmacokinetics and Dosimetry of Tc 99m Tilmanocept Following a Single Intravenous Dose Administration in Male and Female Subjects Diagnosed

  6. Drug

    Telbivudine

    go.drugbank.com/drugs/DB01265
    ApprovedWithdrawn

    Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects.

  7. Drug

    Carbidopa

    go.drugbank.com/drugs/DB00190
    ApprovedInvestigational

    It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier.

    Mixtures: Dom-levo-carbidopa, LEVODOPA/CARBIDOPA/ENTACAPONE DOC
  8. Target

    Esterase EstA

    go.drugbank.com/bio_entities/BE0003982
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    Esterase whose enzymatic activity is required for rhamnolipid production, all kinds of cell motility (swimming, swarming, and twitching), and biofilm formation; the exact role of EstA in these processes is unclear. In vitro, has pronounc...

    Synonyms: papA
  9. Drug

    Conestat alfa

    go.drugbank.com/drugs/DB09228
    Approved

    It does this through inhibition of several target proteases within these pathways including activated C1s, kallikrein, factor XIIa and factor XIa.

  10. Drug

    Pyridoxine

    go.drugbank.com/drugs/DB00165
    ApprovedInvestigationalNutraceuticalVet approved

    Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for nor...

    Mixtures: SIN SED POLVO (PARA BEBIDA HIDRATANTE VITAMINADA), Tricare Prenatal 2-part Daily Prenatal Vitamin SystemCategories: Vitamin B Complex