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Displaying results 1291 - 1300 of 10000 in total
  1. Drug

    Diazoxide

    go.drugbank.com/drugs/DB01119
    ApprovedInvestigational

    [A255647,L44612] It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. … [A255647,L44612] In March 2025, an extended-release formulation of diazoxide choline was approved by the FDA for the treatment of hyperphagia in patients with Prader-Willi syndrome, becoming the first

    Categories: Arteriolar Smooth Muscle, Agents Acting OnProducts: Hyperstat Inj 15mg/ml, Proglycem Susp 50mg/ml
  2. Drug

    Isradipine

    go.drugbank.com/drugs/DB00270
    Approved

    Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. … It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class.

    Categories: Calcium-Regulating Hormones and AgentsProducts: VASCAL UNO 5MG, ISRADIPINO 2.5MG TABLETAS
  3. Target

    Sodium- and chloride-dependent glycine transporter 1

    go.drugbank.com/bio_entities/BE0000940
    TransporterTargetHumans

    Sodium- and chloride-dependent glycine transporter (PubMed:37962965, PubMed:8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses

    Polypeptides: Sodium- and chloride-dependent glycine transporter 1
  4. Target

    Troponin C, slow skeletal and cardiac muscles

    go.drugbank.com/bio_entities/BE0001024
    TargetHumans

    Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.

    Polypeptides: Troponin C, slow skeletal and cardiac muscles
  5. Target

    Sodium- and chloride-dependent glycine transporter 2

    go.drugbank.com/bio_entities/BE0002310
    TransporterTargetHumans

    Sodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349).

    Polypeptides: Sodium- and chloride-dependent glycine transporter 2
  6. Target

    Signal transducer and activator of transcription 3

    go.drugbank.com/bio_entities/BE0003462
    TargetHumans

    and IL6ST) (PubMed:9188471) … Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity

    Polypeptides: Signal transducer and activator of transcription 3
  7. Target

    Disintegrin and metalloproteinase domain-containing protein 17

    go.drugbank.com/bio_entities/BE0003754
    TargetHumans

    Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. … and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481, PubMed:38771644).

    Polypeptides: Disintegrin and metalloproteinase domain-containing protein 17
  8. Target

    Macrophage scavenger receptor types I and II

    go.drugbank.com/bio_entities/BE0010942
    TargetHumans

    Recognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation … Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate

    Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Macrophage acetylated LDL receptor I and II
  9. Target

    Cleavage and polyadenylation specificity factor subunit 3

    go.drugbank.com/bio_entities/BE0021153
    TargetHumans

    and other factors to bring about cleavage and poly(A) addition. … Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity)

    Polypeptides: Cleavage and polyadenylation specificity factor subunit 3Synonyms: Cleavage and polyadenylation specificity factor 73 kDa subunit
  10. Drug

    Betamethasone

    go.drugbank.com/drugs/DB00443
    ApprovedInvestigationalVet approved

    [A192444] It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. … Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties.

    Mixtures: Throwers Pbc No. 1, TUDERM-NCategories: Alimentary Tract and Metabolism, Sex Hormones and Insulins