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Displaying results 1311 - 1320 of 10000 in total
  1. Drug

    Aminobenzoic acid

    go.drugbank.com/drugs/DB02362
    ApprovedWithdrawn

    A member of the vitamin B complex. It used to be common in sunscreening agents until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic skin disorders.

    Synonyms: 1-Amino-4-carboxybenzene, 4-aminobenzoateMixtures: KORDEL`S NUTRITIME TABLET, Multi B Complex Plus 500mg Vitamin C Tablets
  2. Pathway

    Azathioprine Action Pathway

    smpdb.ca/view/SMP0000427
    Drug action

    Azathioprine is a purine antimetabolite prodrug that exerts cytotoxic effects via three mechanisms: via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA, inhibition of de novo synthesis of...

    Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 more
    Enzymes: Thiopurine S-methyltransferase
  3. Pathway

    Mercaptopurine Action Pathway

    smpdb.ca/view/SMP0000428
    Drug action

    Mercaptopurine is a purine antimetabolite prodrug that exerts cytotoxic effects via three mechanisms: via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA, inhibition of de novo synthesis ...

    Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +26 more
    Enzymes: Thiopurine S-methyltransferase
  4. Target

    Dual specificity mitogen-activated protein kinase kinase 5

    go.drugbank.com/bio_entities/BE0009460
    TargetHumans

    Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac d...

    Synonyms: MEK 5
  5. Drug

    Metoprolol

    go.drugbank.com/drugs/DB00264
    ApprovedInvestigational

    Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release. … [T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.

    Synonyms: 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol, (RS)-MetoprololMixtures: METOPROLOL HCT S 100/12.5, METOPROLOL HCT S 100/12.5
  6. Pathway

    Thioguanine Action Pathway (old)

    smpdb.ca/view/SMP0000430
    Drug action

    Thioguanine is a purine antimetabolite prodrug closely related to mercaptopurine and similarly inhibits purine metabolism. The thioguanine pathway is shown as a part of the mercaptopurine pathway. Thioguanine exerts cytotoxic effects via...

    Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 more
    Enzymes: Thiopurine S-methyltransferase
  7. Drug

    Rice bran

    go.drugbank.com/drugs/DB14361
    Approved

    Rice bran is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

    Mixtures: Ari S-Liner
  8. Drug

    Bisacodyl

    go.drugbank.com/drugs/DB09020
    ApprovedInvestigational

    Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation. … [A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956[L33045] but has been used as a laxative since 1952.[A233300]

    Synonyms: Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)Mixtures: Gentlax S, BEKUNIS 3 MG/5 MG KAPLI TABLET, 30 ADET
  9. Drug

    Verubecestat

    go.drugbank.com/drugs/DB12285
    Investigational

    In July 2013, Merck announced positive results for Phase Ib trials of Verubecestat. … Verubecestat is Merck’s investigational oral β-site amyloid precursor protein cleaving enzyme (BACE1 or β secretase) inhibitor.

    Categories: Heterocyclic Compounds, 1-Ring
  10. Drug

    Foreskin fibroblast (neonatal)

    go.drugbank.com/drugs/DB10770
    Approved

    Dermagraft has been combined with [DB10772] to create a drug beneficial to patients with open burn wounds [L2427]. … Also known as Dermagraft, this device is a cryopreserved human fibroblast-derived dermal substitute.