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Displaying results 1341 - 1350 of 10000 in total
  1. Pathway

    Prochlorperazine - Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126629
    Drug action

    Prochlorperazine is administered orally. It is a phenothiazine derivative, used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Dopamine-antagonizing medications such as prochlorperazine are thoug...

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Prochlorperazine · Dopamine · Levodopa +2 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  2. Drug

    Trimethoprim

    go.drugbank.com/drugs/DB00440
    ApprovedInvestigationalVet approved

    [L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of … Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it

    Mixtures: TS-BAC, TS-BACCategories: MATE 1 Inhibitors, MATE 1 Substrates
  3. Drug

    Zinc sulfate

    go.drugbank.com/drugs/DB09322
    ApprovedInvestigational

    Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". … It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

    Mixtures: Micro+ Te Pediatric, M T E 4 Concentrate InjProducts: SULFATO DE ZINC 2MG/ML SOLUCION ORAL SABOR A CEREZA Y SABOR A CHICLE., EYE GLO RELIEF EYE DROPS 0.25%w/v
  4. Drug

    Nicorandil

    go.drugbank.com/drugs/DB09220
    ApprovedInvestigationalWithdrawn

    Nicorandil is an orally efficacious vasodilatory drug and antianginal agent marketed in the UK, Australia, most of Europe, India, Philippines, Japan, South Korea, and Taiwan. … It is shown to dilate normal and stenotic coronary arteries and reduces both ventricular preload and afterload [A20325].

    Synonyms: N-(2-Hydroxyethyl)nicotinamide nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate (ester)International brands: K-Cor
  5. Drug

    Sepetaprost

    go.drugbank.com/drugs/DB12043
    Investigational

    Sepetaprost has been used in trials studying the treatment of Open Angle-glaucoma, Ocular Hypertension, and Mild Open Angle-glaucoma (OAG).

    Categories: Heterocyclic Compounds, 1-Ring
  6. Drug

    Sulisobenzone

    go.drugbank.com/drugs/DB11185
    Approved

    Sulisobenzone is approved by the FDA in concentrations of up to 10% and in Canada, is approved by Health Canada at the same concentrations [F38]. … As a group, benzophenones may be used to delay photodegradation or extend shelf life in toiletries and plastic surface coatings [L2671].

    Salts: Benzophenone-5Mixtures: Nioxin Scalp Treatment System 6 SPF 15 Sunscreen - Medium to Coarse Hair, Rayito de Sol
  7. Drug

    Ferrous sulfate anhydrous

    go.drugbank.com/drugs/DB13257
    ApprovedInvestigational

    [A190528] Ferrous sulfate is a synthetic agent used in the treatment of iron deficiency. It is the gold standard of oral iron therapy in the UK and many other countries.[L2234,L2246] … [A190804] This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells.

    Mixtures: Hormodausse Plus Calc Et D Tab, TL-Fol 500Synonyms: iron sulfate (1:1), iron(2+) sulfate (anhydrous)
  8. Drug

    Phenobarbital

    go.drugbank.com/drugs/DB01174
    ApprovedInvestigational

    A barbituric acid derivative that acts as a nonselective central nervous system depressant. … It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.

    Mixtures: Se-donna Pb Hyos, Re-PB HyosCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C18 Substrates with a Narrow Therapeutic Index
  9. Drug

    Trastuzumab deruxtecan

    go.drugbank.com/drugs/DB14962
    ApprovedInvestigational

    [L10842] It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of its class. … Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers.

    Categories: MATE 2 Substrates, P-glycoprotein substratesSynonyms: T-DXd, T- DXd
  10. Drug

    Sulfamethoxazole

    go.drugbank.com/drugs/DB01015
    ApprovedInvestigational

    [L11830] In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial infections, including those of the urinary, respiratory, and gastrointestinal tracts. … [L11830] It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps

    Mixtures: TS-BAC, TS-BACCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors