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Tecovirimat
go.drugbank.com/drugs/DB12020ApprovedInvestigational[A35133,L3614] Tecovirimat is an antiviral drug that was identified via a high-throughput screen in 2002. … [A35133] It is effective against all orthopoxviruses, including vaccinia, cowpox, ectromelia, rabbitpox, monkeypox, and Variola (smallpox) virus.
Ruxolitinib
go.drugbank.com/drugs/DB08877ApprovedInvestigational[A229708] In 2014, it was approved for the treatment of polycythemia vera in adults who have an inadequate response to or are intolerant of [hydroxyurea] and in 2019, ruxolitinib was approved for use in … It is a potent and selective inhibitor of JAK1 and JAK2,[A229698] which are tyrosine kinases involved in cytokine signalling and hematopoiesis.
Nateglinide
go.drugbank.com/drugs/DB00731ApprovedIt should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. … Nateglinide is extensively metabolized in the liver and excreted in urine (83%) and feces (10%). The major metabolites possess less activity than the parent compound.
Categories: Drugs Used in DiabetesMethylchloroisothiazolinone
go.drugbank.com/drugs/DB14197ApprovedIt is found within many commercially available cosmetics, lotions, and makeup removers. … It is also a known dermatological sensitizer and allergen; some of its side effects include flaky or scaly skin, breakouts, redness or itchiness, and moderate to severe swelling in the eye area.
Categories: Compounds used in a research, industrial, or household settingMethocarbamol
go.drugbank.com/drugs/DB00423ApprovedInvestigationalVet approvedMethocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether. … [L6295] A combination product with [acetylsalicylic acid] and [codeine] is available in Canada by prescription.[L6295] Methocarbamol was FDA approved on 16 July 1957.[L6265]
Mixtures: ML-PRIMProducts: Robaxin Inj 100mg/ml, Robaximol Inj 100mg/mlBorage oil
go.drugbank.com/drugs/DB11238ApprovedBorage oil may be found in foods or in skin care products. … Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage).
Mixtures: SEVEN SEAS EVENING PRIMROSE OIL PLUS STARFLOWER OIL 1000MG CAPSULE, Borage Oil CapsulesSynonyms: Borage oil, borage seed oilPramipexole
go.drugbank.com/drugs/DB00413ApprovedInvestigationalIt was first approved by the FDA in 1997 [L5882]. … It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement) [A176867].
Products: PRAMIPEXOL AL 2.1MG RET, PRAMIPEXOL AL 0.26MG RETElvitegravir
go.drugbank.com/drugs/DB09101ApprovedInvestigationalElvitegravir was first licensed from Japan Tobacco in 2008 and developed by Gilead Sciences. It was FDA approved on August 27, 2012. … Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.
Categories: Antivirals used in combination for the treatment of HIV infectionsSynonyms: 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acidMenadione
go.drugbank.com/drugs/DB00170ApprovedNutraceuticalA synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Products: VI-PLEX K 10 MG/2 ML AMPUL, 5 ADET, VI-PLEX K 10 MG/2 ML AMPUL, 50 ADETEladocagene exuparvovec
go.drugbank.com/drugs/DB16780ApprovedInvestigationalEladocagene exuparvovec is a recombinant adeno-associated virus-2 (AAV2)-based gene therapy that expresses human aromatic L-amino acid decarboxylase (AADC), and it is used to treat AADC deficiency, a fatal … [A253687] It was subsequently approved by the FDA in November 2024.[L51898,L51893]