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Displaying results 131 - 140 of 134502 in total
  1. Pathway

    Lansoprazole Metabolism Pathway (old)

    smpdb.ca/view/SMP0000614
    Drug metabolism

    This active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus. … In this pathway, lansoprazole is taken orally and is oxidized in the stomach to form the active metabolite of lansoprazole.

    Drugs: Lansoprazole
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  2. Pathway

    Pantoprazole Metabolism Pathway

    smpdb.ca/view/SMP0000615
    Drug metabolism

    This active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus. … Because the drug binds covalently, its effects are dose-dependent and last much longer than similar drugs that bind to the protein non-covalently.

    Drugs: Pantoprazole
    Enzymes: Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta
  3. Pathway

    Hydrochlorothiazide Diuretic Action Pathway

    smpdb.ca/view/SMP0122688
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … The apical membrane contains a calcium channel that transports calcium from the lumen into the epithelial cell, a potassium channel that transports K+ out of the epithelial cell, and a Na+/Cl- cotransporter

    Drugs: Hydrochlorothiazide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Hydroflumethiazide Diuretic Action Pathway

    smpdb.ca/view/SMP0123142
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. … The apical membrane contains a calcium channel which transports calcium from the lumen into the epithelial cell, a potassium channel which transports K+ out of the epithelial cell and a Na+/Cl- cotransporter

    Drugs: Hydroflumethiazide · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  5. Pathway

    Chlorthalidone Diuretic Action Pathway

    smpdb.ca/view/SMP0123149
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … The apical membrane contains a calcium channel that transports calcium from the lumen into the epithelial cell, a potassium channel that transports K+ out of the epithelial cell, and a Na+/Cl- cotransporter

    Drugs: Chlorthalidone · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Pathway

    Acebutolol Action Pathway

    smpdb.ca/view/SMP0000296
    Drug action

    Adrenaline (also known as epinephrine) can activate β1 adrenergic receptor so that the heart rate and output will be increased. … Acebutolol (also known as Sectral or Prent) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats

    Drugs: ATP · Acebutolol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  7. Pathway

    Penbutolol Action Pathway

    smpdb.ca/view/SMP0000305
    Drug action

    , heart rate and cardiac output. … In juxtaglomerular apparatus, penbutolol can prevent the production of aldosterone and angiotensin II by inhibiting renin production, which lead to prevention of water retention and vasoconstriction.

    Drugs: ATP · Potassium cation · Penbutolol · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  8. Pathway

    Lidocaine (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000328
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … At rest, the cardiac cell membrane is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier potassium channels (I-K1), which allow an outward flow of potassium

    Drugs: NADH · ATP · Lidocaine · Potassium cation · Calcium · Mesoheme +1 more
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  9. Pathway

    Mexiletine Action Pathway

    smpdb.ca/view/SMP0000329
    Drug action

    Membrane ion pumps, such as the sodium-potassium ATPase and sodium-calcium exchanger (NCX), maintain low intracellular sodium (5 mM) and calcium (100 nM) concentrations and high intracellular potassium … At rest, the cardiac cell membrane is impermeable to sodium and calcium ions, but is permeable to potassium ions via inward rectifier potassium channels (I-K1), which allow an outward flow of potassium

    Drugs: ATP · Mexiletine · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4
  10. Pathway

    Carvedilol Action Pathway

    smpdb.ca/view/SMP0000367
    Drug action

    Its activity decreases heart rate, myocardial contractility and oxygen demand and decreases vascular resistance. … Carvedilol, trade name Coreg, is a nonselective beta-blocker that blocks both alpha and beta receptors of the heart and blood vessels.

    Drugs: ATP · Carvedilol · Potassium cation · Calcium
    Enzymes: Potassium channel subfamily K member 1, Inward rectifier potassium channel 4