Search

Displaying results 131 - 140 of 134474 in total
  1. Pathway

    Aminocaproic Acid Action Pathway

    smpdb.ca/view/SMP0000286
    Drug action

    This blockade inhibits plasminogen binding to fibrin and the conversion of plasminogen to plasmin. These prevents fibrin degradation and maintains the stability of fibrin clots. … Aminocaproic acid, brand name Amicar, is a derivate of lysine and is an antifibrinolytic drug. Antifibrinolytics drugs are commonly used during major surgery to prevent significant blood loss.

    Drugs: Aminocaproic acid · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  2. Pathway

    Dicoumarol Action Pathway

    smpdb.ca/view/SMP0000656
    Drug action

    Vitamin K-dependent coagulation factors (II, VII, IX, and X) requires its cofactor, vitamin K to facilitate the activation and gamma-carboxylation. … Inhibition of vitamin K reductase results in reduced concentration of vitamin KH2, which will ultimately lead to decreased coagulability of the blood and reduced cleavage of fibrinogen into fibrin.

    Drugs: Dicoumarol · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor VIII
  3. Pathway

    Bivalirudin.

    smpdb.ca/view/SMP0000277
    Drug action

    The inhibition of fibrin prevents the cleavage of fibrinogen into fibrin which activates Factor XIII and Factor XIIIa. … It binds circulating and clot-bound thrombin at the catalytic site and the anion binding exosite.

    Drugs: Bivalirudin · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor V
  4. Pathway

    Lepirudin Action Pathway

    smpdb.ca/view/SMP0000278
    Drug action

    Lepirudin can also reduce thrombocytopenia and break up clot. … Lepirudin (also known as Refludan) is an anticoagulant that can be used for inhibiting thrombin (prothrombin) irreversibly. Binding of thrombin can prevent formation of clot as well as thrombus.

    Drugs: Lepirudin · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor V
  5. Pathway

    Alteplase Action Pathway

    smpdb.ca/view/SMP0000280
    Drug action

    Alteplase is the generic version of the drugs Activase and Actilyse. It is a thrombolytic drug prescribed to treat acute myocardial infarctions and other blood clotting conditions. … A side effect of the drug is bleeding, angioedema, allergic reactions and fever.

    Drugs: Alteplase · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor V
  6. Pathway

    Anistreplase Action Pathway

    smpdb.ca/view/SMP0000281
    Drug action

    Plasmin breaks down the fibrin of the thrombus to break up the clot and release arterial blockages. … The drug is an acylated streptokinase-plasminogen complex. The acylation of the drug renders it temporarily inactive, protecting it from plasmin inhibitors.

    Drugs: Anistreplase · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor V
  7. Pathway

    Aprotinin Action Pathway

    smpdb.ca/view/SMP0000288
    Drug action

    The inhibition of kallikrein inhibits factor XIIa production to reduce fibrinolysis and coagulation. Inhibition of plasmin slows down fibrinolysis. … Aprotinin, trade name Trasylol is a bovine serine protease inhibitor of trypsin, chymotrypsin, kallikrein and plasmin.

    Drugs: Phylloquinone · Calcium · Aprotinin
    Enzymes: Coagulation factor IX, Coagulation factor V
  8. Pathway

    Streptokinase Action Pathway

    smpdb.ca/view/SMP0000282
    Drug action

    This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X. … Coming back to the factors transported from the liver, coagulation factor X is catalyzed into a group of enzymes called the tenase complex: coagulation factor IX and coagulation factor VIIIa (platelet

    Drugs: Streptokinase · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor V
  9. Pathway

    Urokinase Action Pathway

    smpdb.ca/view/SMP0000284
    Drug action

    This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X. … Coming back to the factors transported from the liver, coagulation factor X is catalyzed into a group of enzymes called the tenase complex: coagulation factor IX and coagulation factor VIIIa (platelet

    Drugs: Urokinase · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor V
  10. Pathway

    Reteplase Action Pathway

    smpdb.ca/view/SMP0000285
    Drug action

    This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X. … Coming back to the factors transported from the liver, coagulation factor X is catalyzed into a group of enzymes called the tenase complex: coagulation factor IX and coagulation factor VIIIa (platelet

    Drugs: Reteplase · Phylloquinone · Calcium
    Enzymes: Coagulation factor IX, Coagulation factor V