Search
Epinastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174947Drug actionEpinastine is an H1 receptor antagonist used to prevent itching in allergic conjunctivitis. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in ord...
Dimetotiazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174953Drug actionDimetotiazine is an H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, alle...
Butriptyline H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174971Drug actionButriptyline is an H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, aller...
Phosphatidylinositol Phosphate Metabolism
smpdb.ca/view/SMP0000463MetabolicPhosphatidylinositol phosphates, or phosphoinositides, are intracellular signaling lipids. Seven different phosphoinositides have been identified in mammals, each distinguished by the number and/or position of the phosphate groups on the...
Simeprevir Action Pathway
smpdb.ca/view/SMP0125950Drug actionSimeprevir is a direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4. Hepatitis C virus lipoviroparticles enter target hepatocytes via recep...
Voxilaprevir Action Pathway
smpdb.ca/view/SMP0125962Drug actionVoxilaprevir is a nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis. The lipoviroparticles attach to LDL...
Fostemsavir Action Pathway
smpdb.ca/view/SMP0125963Drug actionFostemsavir is the phosphonooxymethyl prodrug of temsavir, which is a HIV-1 attachment inhibitor that binds to the gp120 subunit within the HIV-1 gp160 envelope glycoprotein. Fostemavir is the first attachment inhibitor to receive FDA ap...
Amlodipine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126283Drug actionAmlodipine is a calcium channel blocker used to treat hypertension and angina. It can be found under the brand names Amlobenz, Azor, Caduet, Dafiro, Exforge, Exforge Hct, Katerzia, Lotrel, Norliqva, Norvasc, Prestalia, Tribenzor, Twynsta...
Felodipine Action Pathway (New)
smpdb.ca/view/SMP0126294Drug actionFelodipine is a calcium channel blocker used to treat hypertension. It can be found under the brand name Plendil. Felodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calci...
Clevidipine Action Pathway
smpdb.ca/view/SMP0126310Drug actionClevidipine is a dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable. Clevidipine is used IV only and practitioners titrate this drug to lower bl...