Dimetotiazine
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Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Dimetotiazine
- DrugBank Accession Number
- DB08967
- Background
Dimetotiazine has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 391.55
Monoisotopic: 391.138819405 - Chemical Formula
- C19H25N3O2S2
- Synonyms
- Dimetotiazine
- External IDs
- 8599 R.P.
- IL-6302
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAmphetamine Amphetamine may decrease the sedative activities of Dimetotiazine. Benzphetamine Benzphetamine may decrease the sedative activities of Dimetotiazine. Benzylpenicilloyl polylysine Dimetotiazine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent. Betahistine The therapeutic efficacy of Betahistine can be decreased when used in combination with Dimetotiazine. Dextroamphetamine Dextroamphetamine may decrease the sedative activities of Dimetotiazine. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Fonazine mesylate B28V86NGNK 13115-40-7 JGKVKXPDDVRUKC-UHFFFAOYSA-N
Categories
- ATC Codes
- N02CX05 — Dimetotiazine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Benzothiazines
- Sub Class
- Phenothiazines
- Direct Parent
- Phenothiazines
- Alternative Parents
- Alkyldiarylamines / Diarylthioethers / Organosulfonamides / Benzenoids / 1,4-thiazines / Aminosulfonyl compounds / Trialkylamines / Azacyclic compounds / Organopnictogen compounds / Organic oxides show 1 more
- Substituents
- Alkyldiarylamine / Amine / Aminosulfonyl compound / Aromatic heteropolycyclic compound / Aryl thioether / Azacycle / Benzenoid / Diarylthioether / Hydrocarbon derivative / Organic nitrogen compound show 15 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 1FTA475ZDB
- CAS number
- 7456-24-8
- InChI Key
- VWNWVCJGUMZDIU-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3
- IUPAC Name
- 10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulfonamide
- SMILES
- CC(CN1C2=CC=CC=C2SC2=C1C=C(C=C2)S(=O)(=O)N(C)C)N(C)C
References
- Synthesis Reference
British Patent 814,512.
- General References
- Not Available
- External Links
- PubChem Compound
- 3089
- PubChem Substance
- 310264930
- ChemSpider
- 2979
- 50138
- ChEBI
- 135616
- ChEMBL
- CHEMBL346977
- Wikipedia
- Dimetotiazine
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0647 mg/mL ALOGPS logP 3.47 ALOGPS logP 3.34 Chemaxon logS -3.8 ALOGPS pKa (Strongest Basic) 8.99 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 43.86 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 110.46 m3·mol-1 Chemaxon Polarizability 41.79 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-000j-9006000000-b58010dbb2ee7a24a034 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0006-0009000000-61d4c7dd3c7efffcca78 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0f6y-1009000000-fdbf69dae89ac88805cf Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-000j-9041000000-b26834e6ca6fc04fe78c Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-03fr-0095000000-e188438ed94229eafd51 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-059e-9035000000-093d6efed73a0793d5d6 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 181.13966 predictedDeepCCS 1.0 (2019) [M+H]+ 183.49767 predictedDeepCCS 1.0 (2019) [M+Na]+ 190.51167 predictedDeepCCS 1.0 (2019)
Drug created at June 09, 2014 15:37 / Updated at February 21, 2021 18:52