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Displaying results 131 - 140 of 298 in total
  1. Target

    Vitamin K epoxide reductase complex subunit 1

    go.drugbank.com/bio_entities/BE0000713
    TargetEnzymeHumans

    Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.

    Polypeptides: Vitamin K epoxide reductase complex subunit 1
  2. Target

    H subunit of photosynthetic reaction center complex

    go.drugbank.com/bio_entities/BE0003883
    TargetThermochromatium tepidum

    Polypeptides: H subunit of photosynthetic reaction center complex
  3. Target

    ATP synthase F(0) complex subunit a

    go.drugbank.com/bio_entities/BE0009014
    TargetHumans

    ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). … Subunit a, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated

    Polypeptides: ATP synthase F(0) complex subunit aSynonyms: Proton-conducting channel, ATP synthase F(0) complex subunit a
  4. Target

    Target of rapamycin complex 2 subunit MAPKAP1

    go.drugbank.com/bio_entities/BE0018900
    TargetHumans

    Inhibits HRAS and KRAS independently of mTORC2 complex (PubMed:17303383, PubMed:34380736, PubMed:35522713). … Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (PubMed:23727834)

    Polypeptides: Target of rapamycin complex 2 subunit MAPKAP1
  5. Target

    Integrase, catalytic core

    go.drugbank.com/bio_entities/BE0003386
    TargetNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)

    Polypeptides: Integrase, catalytic core
  6. Target

    Neurocan core protein

    go.drugbank.com/bio_entities/BE0004512
    TargetHumans

    May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid

    Polypeptides: Neurocan core protein
  7. Target

    Versican core protein

    go.drugbank.com/bio_entities/BE0004606
    TargetHumans

    May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid

    Polypeptides: Versican core proteinSynonyms: Chondroitin sulfate proteoglycan core protein 2
  8. Drug

    Migalastat

    go.drugbank.com/drugs/DB05018
    ApprovedInvestigational

    Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). This enzyme is responsible for breaking down glycosphingolipid substr...

  9. Target

    Cytochrome b-c1 complex subunit 1, mitochondrial

    go.drugbank.com/bio_entities/BE0001005
    TargetHumans

    The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.

    Polypeptides: Cytochrome b-c1 complex subunit 1, mitochondrialSynonyms: Ubiquinol-cytochrome-c reductase complex core protein 1, Core protein I
  10. Target

    Holliday junction branch migration complex subunit RuvB

    go.drugbank.com/bio_entities/BE0002792
    TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

    The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication … The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.

    Polypeptides: Holliday junction branch migration complex subunit RuvB