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Displaying results 131 - 140 of 10000 in total
  1. Pathway

    Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (Fatty Acid Elongation in Mitochondria)

    smpdb.ca/view/SMP0125748
    Disease

    The estimated birth prevalence of LCHADD is 1 in 62 000 in Northern European individuals. The worldwide birth prevalence is estimated at 1 in 250 000. … MCADD is an autosomal recessive disorder associated with a mutation in the enzyme known as hydroxyacyl-CoA dehydrogenase (HADHA).

    Drugs: NADH · Palmitic Acid
  2. Drug

    Calcium gluconate

    go.drugbank.com/drugs/DB11126
    ApprovedInvestigationalVet approved

    Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. … It can also be taken by mouth but is not recommended by injection into a muscle.

    Mixtures: Multiple Electrolyte Additive Inj, CALCIO AL 10% AMPOLLASProducts: Calcium Gluconate in Sodium Chloride, Calcium Gluconate In Sodium Chloride Injection
  3. Drug

    Methylphenidate

    go.drugbank.com/drugs/DB00422
    ApprovedInvestigational

    In contrast, low doses are found to selectively activate NE and DA neurotransmission within the prefrontal cortex which is an area of the brain thought to play a prominent role in ADHD pathophysiology, … Long-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options

    Products: Ritalin LA, RITALIN LA
  4. Drug

    Ofatumumab

    go.drugbank.com/drugs/DB06650
    ApprovedInvestigational

    It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. … Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells.

    Products: KESIMPTA SOLUTION FOR INJECTION IN PRE-FILLED PEN 20MG/0.4ML, Bonspri 20mg/0.4mL Solution for Injection in Pre-filled syringe
  5. Drug

    Adalimumab

    go.drugbank.com/drugs/DB00051
    ApprovedInvestigational

    This drug is available in a prefilled syringe form and convenient pen form for subcutaneous self-administered doses.[A39983] Several biosimilars to adalimumab. … It is produced by recombinant DNA technology using a mammalian cell expression system.

    Products: HULIO 40MG ILO IN FER, AMGEVITA 40 mg/0.8 ml solution for injection in pre-filled syringe
  6. Drug

    Disopyramide

    go.drugbank.com/drugs/DB00280
    ApprovedInvestigational

    A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar … It also possesses some anticholinergic and local anesthetic properties.

    Categories: Antiarrhythmics, Class Ia, Antiarrhythmics, Class IProducts: Rythmodan-LA, Rythmodan-LA 250mg
  7. Drug

    Paliperidone

    go.drugbank.com/drugs/DB01267
    ApprovedInvestigational

    It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. … It is available as an extended-release tablet, a once-monthly intramuscular injection, an every-three-month intramuscular injection, and a twice-yearly gluteal injection.[L16168,L37744,L4137,L37749]

    Products: Palibon 25 mg Depot-Injektionssuspension in einer Fertigspritze, Palibon 50 mg Depot-Injektionssuspension in einer Fertigspritze
  8. Drug

    Ondansetron

    go.drugbank.com/drugs/DB00904
    ApprovedInvestigationalWithdrawn

    and use, including the development of orally soluble films that are both discreet in administration and less of a burden in comparison to having patients attempt to swallow pills during emesis. … [L5221] The FDA withdrew its approval for the use of all intravenous drug products containing more than 16 mg of ondansetron hydrochloride in a single dose, due to a high risk of QT prolongation.

    Products: Zofran 4mg in 2ml Solution for Injection, Zofran 8mg in 4ml Solution for Injection
  9. Drug

    Gentamicin

    go.drugbank.com/drugs/DB00798
    ApprovedInvestigationalVet approved

    Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. … [A234359,A234364] Although gentamicin is well-established and may be used in a variety of clinical applications, it is also associated with severe adverse effects including nephrotoxicity and ototoxicity

    Mixtures: Gentamicin Sulfate In Nacl 0.9% Inj, Gentamicin Sulfate In Nacl O.9% InjCategories: OCT2 Substrates with a Narrow Therapeutic Index, Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index
  10. Drug

    Potassium hydroxide

    go.drugbank.com/drugs/DB11153
    Approved

    Potassium hydroxide is used in food to adjust pH, as a stabilizer, and as a thickening agent. … Also commonly referred to as _caustic potash_, it is a potent base that is marketed in several forms including pellets, flakes, and powders.

    Mixtures: Kalium-L-malat "Fresenius" 1 molar - Infusionszusatz - Ampullen, NUTRIFLEX PERI IN 2000ML TWIN-FLEXCategories: Compounds used in a research, industrial, or household setting