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Ropivacaine
go.drugbank.com/drugs/DB00296ApprovedInvestigationalIt exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.[L42140] … Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: L-N-n-propylpipecolic acid-2,6-xylidide, (S)-(−)-1-propyl-2',6'-pipecoloxylidideBethanechol
go.drugbank.com/drugs/DB01019ApprovedBethanechol is a synthetic ester that was initially synthesized in 1935. … [A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous
Synonyms: 2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium, carbamyl-β-methylcholineProducts: Myocholine - Glenwood Tabletten 10 mg, ยูโคลีน (5 มิลลิกรัม)Acemetacin
go.drugbank.com/drugs/DB13783ApprovedInvestigationalAcemetacin is a carboxymethyl ester of indometacin. … [A31352] In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin.[T50] It was developed by E.
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 2-RingProducts: RANTUDIL ® LP 90 MG CAPSULAS DE LIBERACIÓN PROLONGADA, RANTUDİL 90 MG UZATILMIŞ SALIMLI KAPSÜL, 10 ADETCladribine
go.drugbank.com/drugs/DB00242ApprovedInvestigationalCladribine is a purine analogue or a chlorinated derivative of adenine [A263733] that causes apoptosis of B and T lymphocytes. … [A350] Cladribine was first approved in the United States in 1993 [A263713] initially as a treatment for a number of hematological malignancies; currently, it is approved for the treatment of hairy cell
Categories: 2-Chloroadenosine, P-glycoprotein substratesSynonyms: (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-6-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purineHydralazine
go.drugbank.com/drugs/DB01275ApprovedInvestigationalOriginally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. … [A186841] Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment of heart failure.
Synonyms: 6-Hydralazine, 1-HydrazinophthalazineInternational brands: Cesoline Y, Cesoline WDihydrocodeine
go.drugbank.com/drugs/DB01551ApprovedIllicitIt is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis … Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough.
Mixtures: J-cof Dhc, J-max DhcCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPinaverium
go.drugbank.com/drugs/DB09090ApprovedInvestigationalPinaverium is a spasmolytic agent used for functional gastrointestinal disorders. It is a quaternary ammonium compound that acts as an atypical calcium antagonist to restore normal bowel function. … Although it is not a currently approved drug by the FDA, pinaverium is available in over 60 countries including Canada.
Mixtures: BROMUX D® 100/300 MG CÁPSULA., DUOTRYNE®Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingNivolumab
go.drugbank.com/drugs/DB09035ApprovedInvestigationalNivolumab is a fully human IgG4 antibody targeting the immune checkpoint programmed death receptor-1 (PD-1). … [A35203] It was developed by Bristol Myers Squibb.[L12129] Nivolumab was granted FDA approval on 22 December 2014.
Mixtures: OPDUALAG® SOLUCION INYECTABLECategories: Immunoglobulin G, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsLercanidipine
go.drugbank.com/drugs/DB00528ApprovedInvestigationalWithdrawnLercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.
Mixtures: LERCAPREL 20 MG/10 MG, Zanipril 20 mg/10 mg FilmtablettenCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingHydrogen peroxide
go.drugbank.com/drugs/DB11091ApprovedInvestigationalVet approvedHydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. … It is used in industrial and cosmetic applications as a bleaching agent.
Mixtures: K-100, K-100Categories: Compounds used in a research, industrial, or household setting