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Displaying results 1411 - 1420 of 10000 in total
  1. Pathway

    Celecoxib Action Pathway (New)

    smpdb.ca/view/SMP0126384
    Drug action

    COX-2 is expressed heavily in inflamed tissues. … The inhibition of these molecules in inflamed cells leads to the alleviation of pain and inflammation. Celecoxib may cause an increased risk of thrombotic events.

    Drugs: Glutathione · Celecoxib · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
    Enzymes: Prostaglandin E synthase
  2. Pathway

    Glycol salicylate Action Pathway

    smpdb.ca/view/SMP0126550
    Drug action

    The cyclooxygenase pathway begins in the cytosol with phospholipids being converted into arachidonic acid by the action of phospholipase A2. … Prostaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase.

    Drugs: Glutathione · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 · Arachidonic Acid +1 more
    Enzymes: Prostaglandin E synthase
  3. Pathway

    Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126557
    Drug action

    It is mostly found in fish oils. A diet rich in this molecule can be used/started to lower elevated triglycerides level in patients who are hyperglyceridimic. … The anti-inflammatory, antithrombotic, and immunomodulatory actions of EPA are probably due to the role of the molecule in eicosanoid synthesis.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
    Enzymes: Prostaglandin E synthase
  4. Pathway

    Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126563
    Drug action

    Also, this molecule is indicated by the EMA as an adjuvant treatment in secondary prevention after myocardial infarction, in addition to other standard therapy (ie. statins, antiplatelet medicinal products … Prostaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
    Enzymes: Prostaglandin E synthase
  5. Pathway

    Salsalate Action Pathway (New)

    smpdb.ca/view/SMP0126583
    Drug action

    Prostaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase. … Cytokines are produced in the central nervous system (CNS) during an inflammatory response.

    Drugs: Glutathione · Dinoprostone · Calcium · Salsalate · Mesoheme · Prostaglandin G2 +1 more
    Enzymes: Prostaglandin E synthase
  6. Drug

    Pseudoephedrine

    go.drugbank.com/drugs/DB00852
    Approved

    [A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. … Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.

    Mixtures: Cold & Flu-IN-one, Cold & Flu-IN-oneCategories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Adrenergic alpha-1 Receptor Agonists
  7. Drug

    Amivantamab

    go.drugbank.com/drugs/DB16695
    ApprovedInvestigational

    FDA approved the subcutaneous formulation, RYBREVANT FASPRO™, across all existing and expanded indications of amivantamab, including its use as a first-line, chemotherapy-free combination regimen with … [A235133] Amivantamab was granted FDA approval on 21 May 2021,[L34193] followed by the approval by the EMA on 9 December 2021 [L41474] and Health Canada on 30 March 2022.

  8. Drug

    Zinc citrate

    go.drugbank.com/drugs/DB11154
    ApprovedInvestigational

    Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element.

    Mixtures: Vitamin A C E W.niacinam.beta Car.and Min., Collag-EN
  9. Target

    Endothelial PAS domain-containing protein 1

    go.drugbank.com/bio_entities/BE0009679
    TargetHumans

    Transcription factor involved in the induction of oxygen regulated genes. … May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression.

    Synonyms: Class E basic helix-loop-helix protein 73
  10. Drug

    Olmesartan

    go.drugbank.com/drugs/DB00275
    ApprovedInvestigational

    In particular, heart failure is associated with chronic activation of RAAS, leading to inappropriate fluid retention, vasoconstriction, and ultimately a further decline in left ventricular function. … Olmesartan is commonly used for the management of hypertension and Type 2 Diabetes-associated nephropathy, particularly in patients who are unable to tolerate ACE inhibitors.

    Mixtures: OLMESARTAN E AMLODIPINA EG, OLMESARTAN E AMLODIPINA EGCategories: Angiotensin 2 Receptor Blocker, Angiotensin II receptor antagonists