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Neratinib
go.drugbank.com/drugs/DB11828ApprovedInvestigationalNeratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. … Neratinib is currently under investigation for use in many other forms of cancer.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexHexachlorophene
go.drugbank.com/drugs/DB00756ApprovedWithdrawnIt is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797) … A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms.
Teglarinad chloride
go.drugbank.com/drugs/DB05217InvestigationalAlthough the exact mechanism of action has yet to be fully elucidated, GMX1778 appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis. … GMX1777 is a water-soluble prodrug of the cyanoguanidine compound GMX1778 with potential antineoplastic activity.
Eprosartan
go.drugbank.com/drugs/DB00876ApprovedInvestigationalEprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. … By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced.
Mixtures: TEVETEN PLUS 600 MG/12.5 MG FİLM KAPLI TABLET, 28 ADET, TEVETEN PLUS 600 MG/12.5 MG FİLM KAPLI TABLET, 56 ADETProducts: TEVETEN 600 MG FILM KAPLI TABLET, 28 ADETAjmaline
go.drugbank.com/drugs/DB01426ApprovedWithdrawnAn alkaloid found in the root of Rauwolfia serpentina, among other plant sources. … It has also been used for many years as a drug to challenge the conduction system of the heart in cases of bundle branch block and syncope.
Megestrol acetate
go.drugbank.com/drugs/DB00351ApprovedInvestigationalVet approvedA progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. … It has also been used in the palliative treatment of breast cancer.
Categories: Sex Hormones and Modulators of the Genital SystemProducts: BOREA 160 MG TABLET, 30 ADET, MEGACE 160 MG TABLET, 30 ADETCrisaborole
go.drugbank.com/drugs/DB05219ApprovedInvestigationalCrisaborole is a novel oxaborole approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis. … It is currently under development as topical treatment of psoriasis.
Chenodeoxycholic acid
go.drugbank.com/drugs/DB06777ApprovedInvestigationalIt can also reduce the amount of other bile acids that can be harmful to liver cells when levels are elevated. … Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body.
Products: CETEİX 250 MG SERT KAPSÜL, 100 ADET, KENDEO 250 MG SERT KAPSÜL, 100 ADETSilicon dioxide
go.drugbank.com/drugs/DB11132ApprovedSilicon dioxide, or silica, is an oxide of silicon with the chemical formula SiO2. … Colloidal silica is also used as a wine, beer, and juice fining agent or stabilizer.
Mixtures: Supplements De Vitamines Et Mineraux, Dr.Chois KF ToothpasteCategories: Compounds used in a research, industrial, or household settingPergolide
go.drugbank.com/drugs/DB01186ApprovedVet approvedWithdrawnIt is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. … Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome