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Sulbactam
go.drugbank.com/drugs/DB09324ApprovedInvestigationalSulbactam is a beta (β)-lactamase inhibitor and a derivative of the basic penicillin nucleus. … [L50131] When given in combination with β-lactam antibiotics, sulbactam produces a synergistic effect as it blocks the enzyme responsible for drug resistance by hydrolyzing β-lactams.[A263296]
Mixtures: AMPICILLINA E SULBACTAM IBI, AMPICILLINA E SULBACTAM IBI3-Methylfentanyl
go.drugbank.com/drugs/DB01571ExperimentalIllicit3-Methylfentanyl is an opioid analgesic and is an analog of the potent opioid, fentanyl. 3-Methylfentanyl is one of the most powerful opioid drugs sold illegally and is estimated to be between 400-6000
Sodium sulfate
go.drugbank.com/drugs/DB09472ApprovedInvestigationalVet approvedSodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. … Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions.
Mixtures: Gavilyte G Tm, GaviLyte - C TMDiethylpropion
go.drugbank.com/drugs/DB00937ApprovedIllicitInvestigationalIt is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290) … A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeOliceridine
go.drugbank.com/drugs/DB14881ApprovedInvestigational[A218026, A218031, A218036, A218041, A218046] Oliceridine (formerly known as TRV130) is a "biased agonist" at the μ-opioid receptor by preferentially activating the G-protein pathway with minimal receptor … [A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid receptor subtype is predominantly targeted by and is responsible for the effects of
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeRifamycin
go.drugbank.com/drugs/DB11753ApprovedInvestigationalWithdrawnAll of the derivatives have slight different physicochemical properties when compared to the parent structure. … [L4800] This drug was also sent for review to the EMA in 2015 by Dr. Falk Pharma Gmbh and it was granted a waiver for the tested conditions.[L4801]
Pheniprazine
go.drugbank.com/drugs/DB09250ApprovedWithdrawnPheniprazine was withdrawn by its manufacturer due to its ability to cause toxicity in the liver and its ability to cause optic neuritis. … Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeFlibanserin
go.drugbank.com/drugs/DB04908ApprovedInvestigationalFlibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. … In December of 2025 the FDA expanded the age of the indication to include postmenopausal women, a first for the FDA and sexual health in that age group. [L54893]
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Serotonin Receptor AgonistsMepenzolate
go.drugbank.com/drugs/DB04843ApprovedWithdrawnIt has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications. … Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor.
Conjugated estrogens
go.drugbank.com/drugs/DB00286ApprovedInvestigationalHowever, until 1986 official clinical trials were performed and this product was determined to be effective for the treatment of osteoporosis. … Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.
Categories: Sex Hormones and Modulators of the Genital System