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Displaying results 141 - 150 of 134541 in total
  1. Pathway

    Cocaine Analgesic Action Pathway

    smpdb.ca/view/SMP0125257
    Drug action

    Primarily it acts on sensory neurons in the nasal cavity by inhibiting the sodium channels. Stimulation from touch, pressure, stretch, or pain causes sodium channels on sensory receptors to open. … The different types of sensory neurons it inhibits are mechanoreceptors(pressure, vibrations, and texture), thermoreceptors (temperature), and nociceptors (pain).

    Drugs: Cocaine
    Enzymes: Sodium channel subunit beta-1, Sodium channel protein type 10 subunit alpha
  2. Pathway

    Quinethazone Action Pathway

    smpdb.ca/view/SMP0123030
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … In the cell, it has access to the Na+/Cl- transporter and inhibits it preventing Na+ and Cl- reabsorption.

    Drugs: Quinethazone · Potassium cation · Calcium
    Enzymes: Sodium/calcium exchanger 3, Sodium/potassium-transporting ATPase subunit alpha-1
  3. Pathway

    Indapamide Diuretic Action Pathway

    smpdb.ca/view/SMP0123031
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride into the interstitium-blood.

    Drugs: Indapamide · Potassium cation · Calcium
    Enzymes: Sodium/calcium exchanger 3, Sodium/potassium-transporting ATPase subunit alpha-1
  4. Pathway

    Chlorothiazide Action Pathway

    smpdb.ca/view/SMP0000078
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.

    Drugs: Cysteine · Chlorothiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  5. Pathway

    Bumetanide Action Pathway

    smpdb.ca/view/SMP0000088
    Drug action

    In the nephron, the think ascending limb reabsorbs 25% of sodium and is a good target for diuretics. … This results in the lumen becoming hypertonic and a decreased osmotic gradient thereby reducing the water reabsorption.

    Drugs: Cysteine · Bumetanide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  6. Pathway

    Cyclothiazide Action Pathway

    smpdb.ca/view/SMP0000103
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.

    Drugs: Cysteine · Cyclothiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  7. Pathway

    Metolazone Action Pathway (old)

    smpdb.ca/view/SMP0000105
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.

    Drugs: Cysteine · Metolazone · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  8. Pathway

    Torsemide Action Pathway

    smpdb.ca/view/SMP0000118
    Drug action

    This prevents the reuptake of sodium into the Loop of Henle which consequentially reduces the uptake of water and serves to both increase water loss and reduce blood pressure. … It is commonly used to manage hypertension and edema in cases of congestive heart failure as it acts as a diuretic by blocking sodium transporters NKCC2 on the thick ascending limb of the Loop of Henle

    Drugs: Cysteine · Torasemide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  9. Pathway

    Chlorthalidone Action Pathway

    smpdb.ca/view/SMP0000122
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount.

    Drugs: Cysteine · Chlorthalidone · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT
  10. Pathway

    Triamterene Action Pathway

    smpdb.ca/view/SMP0000132
    Drug action

    This primarily contributes to an increase in sodium excretion and consequentially, fluid excretion which decreases blood volume and blood pressure. … Specifically, triamterene inhibits amiloride-sensitive sodium channels which are responsible for the reabsorption of sodium in the late distal convoluted tubule in the nephron.

    Drugs: Cysteine · Triamterene · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Neutral and basic amino acid transport protein rBAT